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Histone deacetylase 4 (HDAC4) nuclear accumulation has been related to neurodegeneration in AT. Since treatment with glucocorticoid analogues has been shown to improve the neurological symptoms that characterize this syndrome, the effects of dexamethasone on HDAC4 were investigated. In this paper, we describe a novel nonepigenetic function of HDAC4 induced by dexamethasone, through which it can directly modulate HIF\u20101a activity and promote the upregulation of the DDIT4 gene and protein expression. This new HDAC4 transcription regulation mechanism leads to a positive effect on autophagic flux, an AT\u2010compromised biological pathway. This signaling was specifically induced by dexamethasone only in AT cell lines and can contribute in explaining the positive effects of dexamethasone observed in AT\u2010treated patients.<\/jats:p>","DOI":"10.1096\/fj.201902039r","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T02:31:35Z","timestamp":1575858695000},"page":"1802-1818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["DDIT4 gene expression is switched on by a new HDAC4 function in ataxia telangiectasia"],"prefix":"10.1096","volume":"34","author":[{"given":"Anastasia","family":"Ricci","sequence":"first","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u201cCarlo Bo\u201d Urbino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Galluzzi","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino 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