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Here, we identify GORAB as a regulator of embryonic alveolar sac formation as genetically disrupting the\n                    <jats:italic>Gorab<\/jats:italic>\n                    gene in mice resulted in fatal saccular maturation defects characterized by a thickened lung mesenchyme. This abnormality is not associated with impairments in cellular proliferation and death, but aberrantly increased protein kinase B (AKT) phosphorylation, elevated\n                    <jats:italic>Vcan<\/jats:italic>\n                    transcription, and enhanced migration of mesenchymal fibroblasts. Genetically augmenting PDGFR\u03b1, a potent activator of AKT in lung mesenchymal cells, recapitulated the alveolar phenotypes, whereas disrupting PDGFR\u03b1 partially rescued alveolar phenotypes in\n                    <jats:italic>Gorab<\/jats:italic>\n                    \u2010deficient mice. Overexpressing or suppressing\n                    <jats:italic>Vcan<\/jats:italic>\n                    in primary embryonic lung fibroblasts could, respectively, mimic or attenuate alveolar sac\u2010like phenotypes in a co\u2010culture model. These findings suggest a role of GORAB in negatively regulating AKT phosphorylation, the expression of\n                    <jats:italic>Vcan<\/jats:italic>\n                    , and the migration of lung mesenchyme fibroblasts, and suggest that alveolar sac formation resembles a patterning event that is orchestrated by molecular signaling and the extracellular matrix in the mesenchyme.\n                  <\/jats:p>","DOI":"10.1096\/fj.201902075r","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T04:12:37Z","timestamp":1581999157000},"page":"4918-4933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["GORAB promotes embryonic lung maturation through antagonizing AKT phosphorylation, versican expression, and mesenchymal cell migration"],"prefix":"10.1096","volume":"34","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Laboratory 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