{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:00:53Z","timestamp":1793412053291,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000965","name":"American Federation for Aging Research","doi-asserted-by":"publisher","award":["A16034"],"award-info":[{"award-number":["A16034"]}],"id":[{"id":"10.13039\/100000965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL119587"],"award-info":[{"award-number":["HL119587"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL141127"],"award-info":[{"award-number":["HL141127"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL106173"],"award-info":[{"award-number":["HL106173"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM095467"],"award-info":[{"award-number":["GM095467"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM105949"],"award-info":[{"award-number":["GM105949"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inflammation\u2010resolution is mediated by the balance between specialized pro\u2010resolving mediators (SPMs) like resolvin D1 (RvD1) and pro\u2010inflammatory factors, like leukotriene B\n                    <jats:sub>4<\/jats:sub>\n                    (LTB\n                    <jats:sub>4<\/jats:sub>\n                    ). A key cellular process of inflammation\u2010resolution is efferocytosis. Aging is associated with defective inflammation\u2010resolution and the accumulation of pro\u2010inflammatory senescent cells (SCs). Therefore, understanding mechanism(s) that underpin this impairment is a critical gap. Here, using a model of hind limb ischemia\u2010reperfusion (I\/R) remote lung injury, we present evidence that aging is associated with heightened inflammation, impaired SPM:LT ratio, defective efferocytosis, and a decrease in MerTK levels in injured lungs. Treatment with RvD1 mitigated I\/R lung injury in aging, promoted efferocytosis, and prevented the decrease of MerTK in injured lungs from old mice. Old MerTK cleavage\u2010resistant mice (MerTK\n                    <jats:sup>CR<\/jats:sup>\n                    ) exhibited less neutrophils or polymorpho nuclear cells infiltration and had improved efferocytosis compared with old WT controls. Mechanistically, macrophages that were treated with conditioned media (CM) from senescent cells had increased MerTK cleavage, impaired efferocytosis, and a defective RvD1:LTB\n                    <jats:sub>4<\/jats:sub>\n                    ratio. Macrophages from MerTK\n                    <jats:sup>CR<\/jats:sup>\n                    mice were resistant to CM\u2010induced efferocytosis defects and had an improved RvD1:LTB\n                    <jats:sub>4<\/jats:sub>\n                    ratio. RvD1\u2010stimulated macrophages prevented CM\u2010induced MerTK cleavage and promoted efferocytosis. Together, these data suggest a new mechanism and a potential therapy to promote inflammation\u2010resolution and efferocytosis in aging.\n                  <\/jats:p>","DOI":"10.1096\/fj.201902126r","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:09:18Z","timestamp":1574813358000},"page":"597-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Resolvin D1 promotes efferocytosis in aging by limiting senescent cell\u2010induced MerTK cleavage"],"prefix":"10.1096","volume":"34","author":[{"given":"Nicholas","family":"Rymut","sequence":"first","affiliation":[{"name":"The Department of Molecular and Cellular Physiology Albany Medical College Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Heinz","sequence":"additional","affiliation":[{"name":"The Department of Molecular and Cellular Physiology Albany Medical College Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeshna","family":"Sadhu","sequence":"additional","affiliation":[{"name":"The Department of Molecular and Cellular Physiology Albany Medical College Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Hosseini","sequence":"additional","affiliation":[{"name":"The Department of Molecular and Cellular Physiology Albany Medical College Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin O.","family":"Riley","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Center for Experimental Therapeutics and Reperfusion Injury Brigham and Women's Hospital and Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Marinello","sequence":"additional","affiliation":[{"name":"The Department of Molecular and Cellular Physiology Albany Medical College Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson","family":"Maloney","sequence":"additional","affiliation":[{"name":"The Department of Immunology and Microbial Disease Albany Medical College Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine C.","family":"MacNamara","sequence":"additional","affiliation":[{"name":"The Department of Immunology and Microbial Disease Albany Medical College Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Spite","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Center for Experimental Therapeutics and Reperfusion Injury Brigham and Women's Hospital and Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Fredman","sequence":"additional","affiliation":[{"name":"The Department of Molecular and Cellular Physiology Albany Medical College Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3547"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13479"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2294"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2675"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401313"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03658.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524292113"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90520"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aar3721"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.263020"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2233"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00166.2014"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7592-1_4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-239-1_10"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.167197"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12859"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.07.015"},{"key":"e_1_2_9_20_1","first-page":"137","article-title":"Ischemia\u2010reperfusion injury","volume":"41","author":"Seekamp A","year":"1993","journal-title":"Agents Actions Suppl"},{"issue":"2","key":"e_1_2_9_21_1","first-page":"ii32\u2010ii43","article-title":"Vascular surgery\u2010related organ injury and protective strategies: update and future prospects","volume":"117","author":"Yang B","year":"2016","journal-title":"Br J Anaesth"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.8.4267"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358899"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031557"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12223"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124213"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-423525"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.8117"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.07.002"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700397"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(93)90024-L"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311327"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410851111"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2005.04.004"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.209908"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01464"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091082"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7227rev"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05877"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe058042"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0306"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08541"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2015.11.003"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201902126R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201902126R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201902126R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:49:15Z","timestamp":1761677355000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201902126R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,26]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1096\/fj.201902126R"],"URL":"https:\/\/doi.org\/10.1096\/fj.201902126r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,26]]},"assertion":[{"value":"2019-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}