{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:24:49Z","timestamp":1785291889780,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS042617"],"award-info":[{"award-number":["NS042617"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The purpose of this study was to characterize the effects of tocotrienol form of vitamin E (TCT) on platelet function in patients with stroke or transient ischemic attack (TIA). A double blind, randomized, single center phase II clinical trial was conducted comparing placebo (PBO) and 400 and 800\u00a0mg TCT daily for a year in 150 patients with a sentinel ischemic stroke or TIA event in the prior 6\u00a0months. Platelet function was measured at baseline and then, at 3\u00a0month intervals for a year, using light transmission aggregometry. The incidence of aspirin resistance in aspirin\u2010treated patients or platelet inhibition in patients on clopidogrel alone was compared between the three treatment groups. Results showed that in patients taking aspirin and clopidogrel, the incidence of aspirin resistance was significantly decreased from 40% in PBO\u2010treated patients to 9% in the 400\u00a0mg TCT group and 25% in the TCT 800\u00a0mg group (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.03). In conclusion, patients on aspirin and clopidogrel had a higher incidence of aspirin resistance than all patients treated with aspirin alone and TCT decreased the frequency of aspirin resistance in this group.\n                  <\/jats:p>","DOI":"10.1096\/fj.201902216rr","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T05:08:55Z","timestamp":1595221735000},"page":"11838-11843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Platelet function in stroke\/transient ischemic attack patients treated with tocotrienol"],"prefix":"10.1096","volume":"34","author":[{"given":"Andrew","family":"Slivka","sequence":"first","affiliation":[{"name":"Department of Neurology The Ohio State University Wexner Medical Center Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Rink","sequence":"additional","affiliation":[{"name":"Department of 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