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Protein arginine methyltransferase 7 (\n                    <jats:italic>Prmt7<\/jats:italic>\n                    ), a type III arginine methyltransferase, catalyzes the formation of stable monomethylarginines of histones. The role of PRMT7 in virus\u2010induced innate immunity signaling, however, remains largely unknown. We demonstrate that zebrafish\n                    <jats:italic>prmt7<\/jats:italic>\n                    could be inhibited by spring viremia of carp virus (SVCV) and grass carp reovirus (GCRV) infection. The overexpression of\n                    <jats:italic>prmt7<\/jats:italic>\n                    suppresses cellular antiviral responses that are partially dependent on the arginine methyltransferase activity of\n                    <jats:italic>prmt7<\/jats:italic>\n                    . Consistently,\n                    <jats:italic>prmt7<\/jats:italic>\n                    \u2010null zebrafish were more resistant to SVCV or GCRV infection, exhibiting enhanced expression of key antiviral genes and fewer necrotic cells in the liver and kidney upon viral infection. Furthermore, we established a zebrafish model to investigate grass carp hemorrhagic disease. Our findings suggest that by suppressing the RIG\u2010I\u2010like receptors signaling, zebrafish\n                    <jats:italic>prmt7<\/jats:italic>\n                    negatively regulates antiviral responses, indicating the vital role of\n                    <jats:italic>prmt7<\/jats:italic>\n                    and its arginine methyltransferase activity in innate immunity.\n                  <\/jats:p>","DOI":"10.1096\/fj.201902219r","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T10:48:48Z","timestamp":1574938128000},"page":"988-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Zebrafish\n                    <i>prmt7<\/i>\n                    negatively regulates antiviral responses by suppressing the retinoic acid\u2010inducible gene\u2010I\u2010like receptor signaling"],"prefix":"10.1096","volume":"34","author":[{"given":"Junji","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan P.R. 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