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The chronic obesity is associated with metabolic disorders, such as hyperglycemia, hyperlipidemia, fatty liver, and cadiovascular disease, which cause high risk for mortality. The novel potential strategy to overcome obesity is to \u201cburn out\u201d the extra fat via \u201cbrowning\u201d of the white adipose tissues. The phytochemical resveratrol (Res) has attracted substantial attention due to its powerful amelioratory effects in metabolic diseases. However, how Res regulates the browning of adipose tissues remains largely elusive. Our data show that the NAD\n                    <jats:sup>+<\/jats:sup>\n                    \u2010dependent deacetylase silent information regulator 1 (Sirt1) mediates Res\u2010induced browning and fat reduction of adipocytes, as well as other Res\u2010improved metabolic phenotypes including hyperglycemina and hyperlipidemia in mice. Interestingly, we found that the major metabolites of Res in vivo (Res\u20103\u2010O\u2010glucuronide, Res\u20104\u2032\u2010O\u2010glucuronide, and Res\u20103\u2010O\u2010sulfate) were much less potent in promoting browning gene expressions and reducing fat content in comparison to Res itself in mouse and human adipocytes\u00a0in vitro, suggesting the importance and necessarity to enhance the bioavailability of Res in vivo in consideration of therapeutic application. Taken together, our findings clarify the beneficial effects of Res on excess fat utilization via promotion of browning in a Sirt1\u2010dependent manner, suggesting the potential therapeutic application of Res in the treatment of obesity and related metabolic disorders.\n                  <\/jats:p>","DOI":"10.1096\/fj.201902222r","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T07:38:35Z","timestamp":1580456315000},"page":"4527-4539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Resveratrol promotes white adipocytes browning and improves metabolic disorders in Sirt1\u2010dependent manner\u00a0in mice"],"prefix":"10.1096","volume":"34","author":[{"given":"Zilun","family":"Li","sequence":"first","affiliation":[{"name":"Division of Vascular Surgery The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou P.R. 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