{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:24:30Z","timestamp":1761704670115,"version":"build-2065373602"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Mu1376\/11\u20101","Mu1376\/11\u20103"],"award-info":[{"award-number":["Mu1376\/11\u20101","Mu1376\/11\u20103"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    ICER (inducible cAMP early repressor) isoforms are transcriptional repressors encoded by the\n                    <jats:italic>Crem<\/jats:italic>\n                    (cAMP responsive element modulator) gene. They were linked to the regulation of a multitude of cellular processes and pathophysiological mechanisms. Here, we show for the first time that two independent induction patterns for CREM repressor isoforms exist in the heart, namely for ICER and smICER (small ICER), which are induced in response to \u03b2\u2010adrenergic stimulation in a transient\u2010 and saturation\u2010like manner, respectively. This time\u2010shifted induction pattern, driven by two internal promoters in the\n                    <jats:italic>Crem<\/jats:italic>\n                    gene, leads to the predominant transcription of\n                    <jats:italic>smIcer<\/jats:italic>\n                    after prolonged \u03b2\u2010adrenergic stimulation. Using an ICER knockout mouse model with preserved smICER induction, we show that the transient\u2010like induction of\n                    <jats:italic>Icer<\/jats:italic>\n                    itself has minor effects on gene regulation, cardiac hypertrophy or contractile function in the heart. We conclude that the functions previously linked to ICER may be rather attributed to smICER, also beyond the cardiac background.\n                  <\/jats:p>","DOI":"10.1096\/fj.201902301rr","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T14:15:32Z","timestamp":1596032132000},"page":"11272-11291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta\u2010adrenergic stimulation"],"prefix":"10.1096","volume":"34","author":[{"given":"Matthias D.","family":"Seidl","sequence":"first","affiliation":[{"name":"Institute of Pharmacology and Toxicology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Fels","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Kranick","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Sternberg","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Grimm","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank T.","family":"St\u00fcmpel","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentina","family":"Pluteanu","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan S.","family":"Schulte","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Heinick","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Kojima","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences Toyo University Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Endo","sequence":"additional","affiliation":[{"name":"Aging Neuroscience Research Team Tokyo Metropolitan Institute of Gerontology Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Huge","sequence":"additional","affiliation":[{"name":"Core Facility Genomik Medical Faculty University of Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Stoll","sequence":"additional","affiliation":[{"name":"Core Facility Genomik Medical Faculty University of Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank U.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35085068"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.11.110195.002035"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4226"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90503-Q"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/8.11.965"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-231977"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.245811"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.11.3923"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.106.000976"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00696-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00056-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009463108"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8072-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0412-08.2008"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0880-06.2006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2165-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.7.2831-2841.2004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90532-U"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.10.015"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000079794.57578.F1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506489102"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000259045.49371.9c"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.11.002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000258451.44949.d7"},{"key":"e_1_2_9_26_1","first-page":"942","article-title":"Feedback mechanisms for cardiac\u2010specific microRNAs and cAMP signaling in electrical remodeling","volume":"8","author":"Myers R","year":"2015","journal-title":"Circulation"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.12.1191"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407864200"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005075"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0532-y"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-269837"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr509"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbs017"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt520"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.101"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-488"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.11.967"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2004.00494.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031798"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2013.02.001"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2012.04.008"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.09.006"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02116.x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3280037"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000165128.39715.87"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01062-06"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204926"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-530"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.11.1.9875"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1096%2Ffj.201902301RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201902301RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201902301RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201902301RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:59:18Z","timestamp":1761688758000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201902301RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1096\/fj.201902301RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.201902301rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"type":"print","value":"0892-6638"},{"type":"electronic","value":"1530-6860"}],"subject":[],"published":{"date-parts":[[2020,6,30]]},"assertion":[{"value":"2019-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}