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Exosomes, which are 30\u2010150\u00a0nm lipid bilayer vehicles, can transfer specific lipid, nucleic acids, proteins, and other bioactive molecules. Exosomes can act as good communication between macrophages and HSCs. Herein, we investigated the role of exosomes between THP\u20101 macrophage and HSCs in the progression of liver fibrosis. Exosomes originating from lipopolysaccharide (LPS)\u2010treated THP\u20101 macrophages promoted HSCs proliferation and induced the increased expression of fibrotic genes. LPS could alter the miRNA profile in exosomes secreted from THP\u20101 macrophages. The changed miR\u2010103\u20103p in exosomes could promote HSCs proliferation and activation by targeting Kr\u00fcppel\u2010like factor 4 (KLF4) and it plays important roles in the crosstalk between THP\u20101 macrophages and HSCs during the progression of liver fibrosis. Moreover, miR\u2010103\u20103p in serum exosomes from liver fibrosis patients could be a biomarker for liver fibrosis. Therefore, exosomes may have important roles in the crosstalk between macrophage and HSCs in the progression of chronic liver diseases.<\/jats:p>","DOI":"10.1096\/fj.201902307rrr","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T06:45:08Z","timestamp":1581749108000},"page":"5178-5192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Exosomal miR\u2010103\u20103p from LPS\u2010activated THP\u20101 macrophage contributes to the activation of hepatic stellate cells"],"prefix":"10.1096","volume":"34","author":[{"given":"Lisha","family":"Chen","sequence":"first","affiliation":[{"name":"Central Laboratory of Department of Neurosurgery The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic 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