{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:53:20Z","timestamp":1790045600775,"version":"4.0.1"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,29]],"date-time":"2019-12-29T00:00:00Z","timestamp":1577577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007393","name":"Association Fran\u00e7aise contre les Myopathies","doi-asserted-by":"publisher","award":["AFM#19814"],"award-info":[{"award-number":["AFM#19814"]}],"id":[{"id":"10.13039\/100007393","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The expression of \u03b1\u2010cardiac actin, a major constituent of the cytoskeleton of cardiomyocytes, is dramatically decreased in a mouse model of dilated cardiomyopathy triggered by inducible cardiac\u2010specific serum response factor (\n                    <jats:italic>Srf<\/jats:italic>\n                    ) gene disruption that could mimic some forms of human dilated cardiomyopathy. To investigate the consequences of the maintenance of \u03b1\u2010cardiac actin expression in this model, we developed a new transgenic mouse based on Cre\/LoxP strategy, allowing together the induction of SRF loss and a compensatory expression of \u03b1\u2010cardiac actin. Here, we report that maintenance of \u03b1\u2010cardiac actin within cardiomyocytes temporally preserved cytoarchitecture from adverse cardiac remodeling through a positive impact on both structural and transcriptional levels. These protective effects were accompanied in vivo by the decrease of ROS generation and protein carbonylation and the downregulation of NADPH oxidases NOX2 and NOX4. We also show that ectopic expression of \u03b1\u2010cardiac actin protects HEK293 cells against oxidative stress induced by H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . Oxidative stress plays an important role in the development of cardiac remodeling and contributes also to the pathogenesis of heart failure. Taken together, these findings indicate that \u03b1\u2010cardiac actin could be involved in the regulation of oxidative stress that is a leading cause of adverse remodeling during dilated cardiomyopathy development.\n                  <\/jats:p>","DOI":"10.1096\/fj.201902389r","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T01:30:05Z","timestamp":1577669405000},"page":"2987-3005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cardioprotective effects of \u03b1\u2010cardiac actin on oxidative stress in a dilated cardiomyopathy mouse model"],"prefix":"10.1096","volume":"34","author":[{"given":"Aude","family":"Angelini","sequence":"first","affiliation":[{"name":"Biological Adaptation and Ageing Institut de Biologie Paris\u2010Seine (IBPS) CNRS UMR 8256, INSERM ERL U1164 Sorbonne Universit\u00e9 Paris 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