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Multiple inflammatory cytokines\/chemokines, such as transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21), activate HSCs, and contribute to the development of hepatic fibrosis. MicroRNAs regulate gene expression at the posttranscriptional level and are involved in regulation of inflammatory cytokine\/chemokine synthesis. In this study, we showed that soluble egg antigen (SEA) stimulation and\n                    <jats:italic>Schistosoma japonicum<\/jats:italic>\n                    infection downregulate miR\u201027b expression and increase KH\u2010type splicing regulatory protein (KSRP) mRNA and protein levels in vitro and in vivo. miR\u201027b regulates the stabilization of TGF\u2010\u03b21 mRNA through targeting KSRP by interacting with their AU\u2010rich elements in hepatocytes and non\u2010parenchymal cells, which has an effect on the activation of HSCs. Importantly, our results have shown that either knockdown miR\u201027b or overexpression of KSRP attenuates\n                    <jats:italic>S. japonicum<\/jats:italic>\n                    \u2010induced hepatic fibrosis in vivo. Therefore, our study highlights the crucial role of miR\u201027b and KSRP in the negative regulation of immune reactions in hepatocyte and non\u2010parenchymal cells in response to SEA stimulation and\n                    <jats:italic>S. japonicum<\/jats:italic>\n                    infection. It reveals that manipulation of miR\u201027b or KSRP might be a useful strategy not only for treating Schistosome\u2010induced hepatic fibrosis but also for curing hepatic fibrosis in general.\n                  <\/jats:p>","DOI":"10.1096\/fj.201902438r","type":"journal-article","created":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T00:35:47Z","timestamp":1579307747000},"page":"4120-4133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Upregulation of KSRP by miR\u201027b attenuates schistosomiasis\u2010induced hepatic fibrosis by targeting TGF\u2010\u03b21"],"prefix":"10.1096","volume":"34","author":[{"given":"Shuhong","family":"Wang","sequence":"first","affiliation":[{"name":"Hubei Province Key Laboratory of Allergy and Immunology School of Basic Medical Sciences Wuhan University Hubei China"},{"name":"Department of Medical Parasitology School of Basic Medical Sciences Wuhan University Hubei 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