{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:15:15Z","timestamp":1790957715705,"version":"4.1.0"},"reference-count":76,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T00:00:00Z","timestamp":1593302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Dorothy P. and Richard P. 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However, the functional role of TOLLIP in IPF is unknown. Using lung tissues from IPF and control subjects, we showed that expression of\n                    <jats:italic>TOLLIP<\/jats:italic>\n                    gene in the lung parenchyma is globally lower in IPF compared to controls. Lung cells expressing significant levels of\n                    <jats:italic>TOLLIP<\/jats:italic>\n                    include macrophages, alveolar type II, and basal cells. TOLLIP protein expression is lower in the parenchyma of IPF lungs but is expressed in the atypical epithelial cells of the distal fibrotic regions. Using overexpression and silencing approaches, we demonstrate that TOLLIP protects cells from bleomycin\u2010induced apoptosis using primary bronchial epithelial cells and BEAS\u20102B cells. The protective effects are mediated by reducing mitochondrial reactive oxygen species (ROS) levels and upregulating autophagy. Therefore, global downregulation of the\n                    <jats:italic>TOLLIP<\/jats:italic>\n                    gene in IPF lungs may predispose injured lung epithelial cells to apoptosis and to the development of IPF.\n                  <\/jats:p>","DOI":"10.1096\/fj.201902636rr","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T14:23:17Z","timestamp":1596032597000},"page":"9884-9898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Toll interacting protein protects bronchial epithelial cells from bleomycin\u2010induced apoptosis"],"prefix":"10.1096","volume":"34","author":[{"given":"Xiaoyun","family":"Li","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine and the Dorothy P. and Richard P. 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