{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:06:07Z","timestamp":1792811167593,"version":"4.5.0"},"reference-count":85,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["Z1AES103311\u201001"],"award-info":[{"award-number":["Z1AES103311\u201001"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The myometrium undergoes structural and functional remodeling during pregnancy. We hypothesize that myometrial genomic elements alter correspondingly in preparation for parturition. Human myometrial tissues from nonpregnant (NP) and term pregnant (TP) human subjects were examined by RNAseq, ATACseq, and PGR ChIPseq assays to profile transcriptome, assessible genome, and PGR occupancy. NP and TP specimens exhibit 2890 differentially expressed genes, reflecting an increase of metabolic, inflammatory, and PDGF signaling, among others, in adaptation to pregnancy. At the epigenome level, patterns of accessible genome change between NP and TP myometrium, leading to the altered enrichment of binding motifs for hormone and muscle regulators such as the progesterone receptor (PGR), Kr\u00fcppel\u2010like factors, and MEF2A transcription factors. PGR genome occupancy exhibits a significant difference between the two stages of the myometrium, concomitant with distinct transcriptomic profiles including genes such as\n                    <jats:italic>ENO1<\/jats:italic>\n                    ,\n                    <jats:italic>LHDA<\/jats:italic>\n                    , and\n                    <jats:italic>PLCL1<\/jats:italic>\n                    in the glycolytic and calcium signaling pathways. Over\u2010representation of SRF, MYOD, and STAT binding motifs in PGR occupying sites further suggests interactions between PGR and major muscle regulators for myometrial gene expression. In conclusion, changes in accessible genome and PGR occupancy are part of the myometrial remodeling process and may serve as mechanisms to formulate the state\u2010specific transcriptome profiles.\n                  <\/jats:p>","DOI":"10.1096\/fj.201902654r","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T04:55:06Z","timestamp":1576126506000},"page":"2252-2268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Dynamic transcriptome, accessible genome, and PGR cistrome profiles in the human myometrium"],"prefix":"10.1096","volume":"34","author":[{"given":"San\u2010Pin","family":"Wu","sequence":"first","affiliation":[{"name":"Reproductive &amp; Developmental Biology Laboratory National Institute of Environmental Health Sciences Research Triangle Park NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew 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