{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:45:30Z","timestamp":1787237130004,"version":"build-2736575974"},"reference-count":82,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002997","name":"Nierstichting","doi-asserted-by":"publisher","award":["15OP03"],"award-info":[{"award-number":["15OP03"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["NWO VICI 016.130.668"],"award-info":[{"award-number":["NWO VICI 016.130.668"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tubular ATP release is regulated by mechanosensation of fluid shear stress (FSS). Polycystin\u20101\/polycystin\u20102 (PC1\/PC2) functions as a mechanosensory complex in the kidney. Extracellular ATP is implicated in polycystic kidney disease (PKD), where PC1\/PC2 is dysfunctional. This study aims to provide new insights into the ATP signaling under physiological conditions and PKD. Microfluidics, pharmacologic inhibition, and loss\u2010of\u2010function approaches were combined to assess the ATP release in mouse distal convoluted tubule 15 (mDCT15) cells. Kidney\u2010specific\n                    <jats:italic>Pkd1<\/jats:italic>\n                    knockout mice (iKsp\u2010\n                    <jats:italic>\n                      Pkd1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    ) and zebrafish\n                    <jats:italic>pkd2<\/jats:italic>\n                    morphants (\n                    <jats:italic>pkd2<\/jats:italic>\n                    \u2010MO) were as models for PKD. FSS\u2010exposed mDCT15 cells displayed increased ATP release. Pannexin\u20101 inhibition and knockout decreased FSS\u2010modulated ATP release. In iKsp\u2010\n                    <jats:italic>\n                      Pkd1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice, elevated renal pannexin\u20101 mRNA expression and urinary ATP were observed. In\n                    <jats:italic>\n                      Pkd1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mDCT15 cells, elevated ATP release was observed upon the FSS mechanosensation. In these cells, increased pannexin\u20101 mRNA expression was observed. Importantly, pannexin\u20101 inhibition in\n                    <jats:italic>pkd2<\/jats:italic>\n                    \u2010MO decreased the renal cyst growth. Our results demonstrate that pannexin\u20101 channels mediate ATP release into the tubular lumen due to pro\u2010urinary flow. We present pannexin\u20101 as novel therapeutic target to prevent the renal cyst growth in PKD.\n                  <\/jats:p>","DOI":"10.1096\/fj.201902901r","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T06:35:09Z","timestamp":1583908509000},"page":"6382-6398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Pannexin\u20101 mediates fluid shear stress\u2010sensitive purinergic signaling and cyst growth in polycystic kidney disease"],"prefix":"10.1096","volume":"34","author":[{"given":"Eric H. J.","family":"Verschuren","sequence":"first","affiliation":[{"name":"Department of Physiology Radboud Institute for Molecular Life Sciences Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Rigalli","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud Institute for Molecular Life Sciences Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Castenmiller","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud Institute for Molecular Life Sciences Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike U.","family":"Rohrbach","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud Institute for Molecular Life Sciences Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 J. 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