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Beside macronutrients, the role of micronutrients, including vitamin D, begins to be explore. The aim of this study was to decipher the impact of maternal vitamin D deficiency (VDD), in normal and high\u2010fat (HF) diet context, on adipose tissue metabolism and energy homeostasis in offspring, considering sex\u2010specific responses. Body weight, energy expenditure, and spontaneous activity was differential impacted in juvenile male and female offspring born from VDD mice. In adulthood, a HF diet combined with maternal VDD disrupted glucose homeostasis and adiposity in male offspring but not in females. Such phenotypes were associated to different transcriptomic profiles in adipose tissue, which could be related to differential modulation of plasma 17\u03b2\u2010estradiol concentrations. Thus, maternal VDD sex\u2010dependently modulated metabolic fate of the offspring, especially when associated with HF diet in adulthood.<\/jats:p>","DOI":"10.1096\/fj.201902924rr","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T14:09:03Z","timestamp":1600956543000},"page":"14905-14919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Prenatal maternal vitamin D deficiency sex\u2010dependently programs adipose tissue metabolism and energy homeostasis in offspring"],"prefix":"10.1096","volume":"34","author":[{"given":"Eva M.","family":"Seipelt","sequence":"first","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, C2VN, INRAE, INSERM Marseille France"},{"name":"Aix\u2010Marseille Universit\u00e9, MMG, INSERM U1251 Marseille 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