{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:57:38Z","timestamp":1790697458352,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102019R1A2B5B01070365"],"award-info":[{"award-number":["NRF\u20102019R1A2B5B01070365"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Thyroid hormones are essential for the regulation of energy homeostasis and metabolic processes. However, the relationship between thyroid function and host gut microbial communities is not properly understood. To determine whether and how gut microbiota is associated with thyroid function, metagenomics analysis of the bacterial population in fecal samples of rat models of hyperthyroidism (induced by levothyroxine) and hypothyroidism (induced by propylthiouracil or thyroidectomy) was conducted through 16S rRNA gene sequencing. Our results revealed that all thyroid dysfunction models were definitely established and gut microbial composition varied according to different thyroid functional status. The relative abundance of\n                    <jats:italic>Ruminococcus<\/jats:italic>\n                    was significantly higher in the hyperthyroidism group (HE) vs both the normal and hypothyroidism groups (HO) while S24\u20107 was significantly higher in the HO group. The population of Prevotellaceae and\n                    <jats:italic>Prevotella<\/jats:italic>\n                    were significantly lower in the HO group vs the normal. Firmicutes and\n                    <jats:italic>Oscillospira<\/jats:italic>\n                    were significantly higher in the SHO (surgery\u2010induced hypothyroidism) group, while Prevotellaceae and\n                    <jats:italic>Prevotella<\/jats:italic>\n                    showed lower abundance in the SHO group than the SHAM group. Present results suggest that thyroid functions may have the potential to influence the profile of gut microbiota and could be used as foundation to investigate interaction mechanism between thyroid and gut microbiome.\n                  <\/jats:p>","DOI":"10.1096\/fj.201903091rr","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T03:01:31Z","timestamp":1588302091000},"page":"8686-8701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Chemically or surgically induced thyroid dysfunction altered gut microbiota in rat models"],"prefix":"10.1096","volume":"34","author":[{"given":"Na Rae","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine of Korean medicine Dongguk University  Republic of 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