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The main focus of AD research has been on the central nervous system (CNS) for long, but in recent years, the gut gained more attention. The intestinal tract is innervated by the enteric nervous system (ENS), built of numerous different types of neurons showing great similarity to neurons of the CNS. It already has been demonstrated that the amyloid precursor protein, which plays a major role in AD pathology, is also expressed in these cells. We analyzed gut tissue of AD model mice (5xFAD) and the respective wild\u2010type littermates at different pathological stages: pre\u2010pathological, early pathological and late pathological. Our results show significant difference in function of the intestine of 5xFAD mice as compared to wild\u2010type mice. Using a pathway array detecting 84 AD\u2010related gene products, we found ApoA1 expression significantly altered in colon tissue of 5xFAD mice. Furthermore, we unveil ApoA1's beneficial impact on cell viability and calcium homeostasis of cultured enteric neurons of 5xFAD animals. With this study, we demonstrate that the intestine is altered in AD\u2010like pathology and that ApoA1 might be one key player within the gut.<\/jats:p>","DOI":"10.1096\/fj.201903128rr","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T04:29:10Z","timestamp":1595046550000},"page":"11883-11899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Alzheimer's disease in the gut\u2014Major changes in the gut of 5xFAD model mice with ApoA1 as potential key player"],"prefix":"10.1096","volume":"34","author":[{"given":"Nicolai M.","family":"Stoye","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center of the Johannes Gutenberg\u2010University Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-0819","authenticated-orcid":false,"given":"Malena","family":"dos Santos 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