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Imbalance of gut microbiota metabolites may lead to cardiac dysfunction in patients with heart failure, which is related to myocardial infarction(MI) severity. However, the role of gut microbiota in the repair process after MI has rarely been reported. To explore the role of gut microbiota in MI repair and its underlying mechanism, we mixed antibiotics in drinking water to interfere with gut microbiota in rats. Hematoxylin and eosin staining, Sirius red staining, western blotting, and immunohistochemistry were used to detect tissue repair and fibrosis. We found that the expressions of alpha\u2010smooth muscle actin, collagen, and histone deacetylase (HDAC) activities were significantly increased. We detected gut microbiota at different time points after MI using 16S ribosomal RNA sequencing and detected that\n                    <jats:italic>Prevotellaceae, Clostridiaceae,<\/jats:italic>\n                    and\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    were significantly altered among the butyric acid producers. We administered sodium butyrate via drinking water and discovered that sodium butyrate reduced HDAC activities and adverse repair. Therefore, we speculated that gut microbiota influences the acetylation level and tissue repair process after MI by affecting butyric acid production.\n                  <\/jats:p>","DOI":"10.1096\/fj.201903129rrr","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T20:34:56Z","timestamp":1612989296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Dynamic modulation of gut microbiota improves post\u2010myocardial infarct tissue repair in rats via butyric acid\u2010mediated histone deacetylase inhibition"],"prefix":"10.1096","volume":"35","author":[{"given":"Tongtong","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pharmacology College of Basic Medical Sciences Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology 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