{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:19:38Z","timestamp":1761704378180,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD071068","P01HD034430"],"award-info":[{"award-number":["R01HD071068","P01HD034430"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL094294"],"award-info":[{"award-number":["T32HL094294"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As loss of contractile function in heart disease could often be mitigated by increased cardiomyocyte number, expansion of cardiomyocyte endowment paired with increased vascular supply is a desirable therapeutic goal. Insulin\u2010like growth factor 1 (IGF\u20101) administration increases fetal cardiomyocyte proliferation and heart mass, but how fetal IGF\u20101 treatment affects coronary growth and function is unknown. Near\u2010term fetal sheep underwent surgical instrumentation and were studied from 127 to 134 d gestation (term\u00a0=\u00a0147 d), receiving either IGF\u20101 LR3 or vehicle. Coronary growth and function were interrogated using pressure\u2010flow relationships, an episode of acute hypoxia with progressive blockade of adenosine receptors and nitric oxide synthase, and by modeling the determinants of coronary flow. The main findings were that coronary conductance was preserved on a per\u2010gram basis following IGF\u20101 treatment, adenosine and nitric oxide contributed to hypoxia\u2010mediated coronary vasodilation similarly in IGF\u20101\u2010treated and Control fetuses, and the relationships between coronary flow and blood oxygen contents were similar between groups. We conclude that IGF\u20101\u2010stimulated fetal myocardial growth is accompanied by appropriate expansion and function of the coronary vasculature. These findings support IGF\u20101 as a potential strategy to increase cardiac myocyte and coronary vascular endowment at birth.<\/jats:p>","DOI":"10.1096\/fj.202000215r","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T14:15:55Z","timestamp":1596032155000},"page":"10041-10055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Coronary vascular growth matches IGF\u20101\u2010stimulated cardiac growth in fetal sheep"],"prefix":"10.1096","volume":"34","author":[{"given":"Sonnet S.","family":"Jonker","sequence":"first","affiliation":[{"name":"Knight Cardiovascular Institute Center for Developmental Health Oregon Health &amp; Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George D.","family":"Giraud","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute Center for Developmental Health Oregon Health &amp; 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