{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:14:25Z","timestamp":1784873665418,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH051699"],"award-info":[{"award-number":["R01MH051699"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    LPA\n                    <jats:sub>1<\/jats:sub>\n                    is one of six known receptors (LPA\n                    <jats:sub>1\u20106<\/jats:sub>\n                    ) for lysophosphatidic acid (LPA). Constitutive\n                    <jats:italic>Lpar1<\/jats:italic>\n                    null mutant mice have been instrumental in identifying roles for LPA\u2010LPA\n                    <jats:sub>1<\/jats:sub>\n                    signaling in neurobiological processes, brain development, and behavior, as well as modeling human neurological diseases like neuropathic pain. Constitutive\n                    <jats:italic>Lpar1<\/jats:italic>\n                    null mutant mice are protected from partial sciatic nerve ligation (PSNL)\u2010induced neuropathic pain, however, the cell types that are functionally responsible for mediating this protective effect are unknown. Here, we report the generation of an\n                    <jats:italic>\n                      Lpar1\n                      <jats:sup>flox\/flox<\/jats:sup>\n                    <\/jats:italic>\n                    conditional null mutant mouse that allows for cre\u2010mediated conditional deletion, combined with a PSNL pain model.\n                    <jats:italic>\n                      Lpar1\n                      <jats:sup>flox\/flox<\/jats:sup>\n                    <\/jats:italic>\n                    mice were crossed with\n                    <jats:italic>cre<\/jats:italic>\n                    transgenic lines driven by neural gene promoters for\n                    <jats:italic>nestin<\/jats:italic>\n                    (all neural cells),\n                    <jats:italic>synapsin<\/jats:italic>\n                    (neurons), or\n                    <jats:italic>P0<\/jats:italic>\n                    (Schwann cells).\n                    <jats:italic>CD11b<\/jats:italic>\n                    \u2010\n                    <jats:italic>cre<\/jats:italic>\n                    transgenic mice were also used to delete\n                    <jats:italic>Lpar1<\/jats:italic>\n                    in microglia. PSNL\u2010initiated pain responses were reduced following cre\u2010mediated\n                    <jats:italic>Lpar1<\/jats:italic>\n                    deletion with all three neural promoters as well as the\n                    <jats:italic>CD11b<\/jats:italic>\n                    promoter, supporting involvement of Schwann cells, central and\/or peripheral neurons, and microglia in mediating pain. Interestingly, rescue responses were nonidentical, implicating distinct roles for\n                    <jats:italic>Lpar1<\/jats:italic>\n                    \u2010expressing cell types. Our results with a new\n                    <jats:italic>Lpar1<\/jats:italic>\n                    conditional mouse mutant expand an understanding of LPA\n                    <jats:sub>1<\/jats:sub>\n                    signaling in the PSNL model of neuropathic pain.\n                  <\/jats:p>","DOI":"10.1096\/fj.202000317r","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T10:37:08Z","timestamp":1595846228000},"page":"8833-8842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Conditional\n                    <i>Lpar1<\/i>\n                    gene targeting identifies cell types mediating neuropathic pain"],"prefix":"10.1096","volume":"34","author":[{"given":"Richard R.","family":"Rivera","sequence":"first","affiliation":[{"name":"Degenerative Disease Program Sanford Burnham Prebys Medical Discovery Institute La Jolla CA 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