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Here, we aim to further investigate the role of GABAergic transmission, especially parvalbumin (PV) interneurons within PrL in the development of ACE\u2010induced anxiety\u2010like behavior, and to assess whether and how electro\u2010acupuncture (EA) therapeutically manage the ACE\u2010induced abnormal behaviors in adulthood. ACE mice exhibited the enhanced anxiety\u2010like behaviors in their adulthood, accompanied by increased GABAergic transmission and PV interneurons in PrL. Chemogenetic blocking PV interneurons in PrL alleviated ACE\u2010enhanced anxiety\u2010like behaviors in mice. Importantly, 37\u2010day EA treatments (mixture of 2\u00a0Hz\/100\u00a0Hz, 1\u00a0mA, 30\u00a0minutes once a day) at the acupoints of Yintang (GV29) and Baihui (GV20) also alleviated ACE\u2010induced anxiety\u2010like behaviors, and rescued ACE\u2010impaired GABAergic neurotransmitter system and PV interneurons in PrL. In parallel, EA treatments further suppressed the activities of pyramidal neurons in PrL, suggesting that EA treatments seem to perform it beneficial effects on the ACE\u2010induced abnormal emotional behaviors by \u201ccalming down\u201d the whole PrL. Collectively, these findings revealed that hyper\u2010function of GABAergic transmission, especially mediating by PV interneurons in PrL may be key etiology underlying ACE\u2010induced anxiety\u2010like behaviors. At least by normalizing the function of GABAergic and PV interneurons, EA may represent a promising therapeutic strategy for managing adolescent substance use\u2010related emotional disorders.<\/jats:p>","DOI":"10.1096\/fj.202000346rr","type":"journal-article","created":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T10:29:27Z","timestamp":1595154567000},"page":"11913-11924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Electro\u2010acupuncture alleviates adolescent cocaine exposure\u2010enhanced anxiety\u2010like behaviors in adult mice by attenuating the activities of PV interneurons in PrL"],"prefix":"10.1096","volume":"34","author":[{"given":"Jiaxun","family":"Nie","sequence":"first","affiliation":[{"name":"Department of Human Anatomy and Histoembryology Nanjing University of Chinese Medicine Nanjing 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