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Recent studies have shown that blood vessels grow from the subchondral bone to the articular cartilage. However, the relationship among inflammation, angiogenesis, and chondrocyte apoptosis is still unclear. We found that chondrocytes could secrete chemokines and VEGF to promote the migration of vascular endothelial cells in response to TNF\u2010\u03b1 stimulation. The invasion of blood vessels leads to increased oxygen tension in the local environment, which increased the expression of SETD7 in chondrocytes by activating the JAK\u2010STAT5 pathway. The bond of phosphorylated STAT5 and the specific locus in the promoter of SETD7 directly increased the transcription of SETD7. On the one hand, SETD7\u2010regulated chemokine expression by forming a positive loop; on the other hand, SETD7\u2010mediated chondrocyte apoptosis by inhibiting the nuclear localization of HIF\u20101\u03b1. In this study, we discovered a novel function of chondrocytes as mediators of inflammation and angiogenesis. Our study demonstrates that SETD7 is a potential molecular target to prevent OA development and progression.<\/jats:p>","DOI":"10.1096\/fj.202000373rrrr","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T08:56:30Z","timestamp":1613984190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis"],"prefix":"10.1096","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4605-0006","authenticated-orcid":false,"given":"Jia","family":"Xiaoshi","sequence":"first","affiliation":[{"name":"Guanghua School of Stomatology Hospital of Stomatology Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"},{"name":"Guangdong Engineering Research Center of Technology and Materials for Oral Reconstruction Guangzhou 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