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Although altered energetics play a central role in MH, MH\u2010susceptible humans and mouse models are often described as having no phenotype until exposure to a triggering agent. The purpose of this study was to determine the influence of the R163C ryanodine receptor 1 mutation, a common MH mutation in humans, on energy expenditure, and voluntary wheel running in mice. Energy expenditure was measured by indirect respiration calorimetry in wild\u2010type (WT) and heterozygous R163C (HET) mice over a range of ambient temperatures. Energy expenditure adjusted for body weight or lean mass was increased (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.05) in male, but not female, HET mice housed at 22\u00b0C or when housed at 28\u00b0C with a running wheel. In female mice, voluntary wheel running was decreased (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.05) in the HET vs WT animals when analyzed across ambient temperatures. The thermoneutral zone was also widened in both male and female HET mice. The results of the study show that the R163C mutations alters energetics even at temperatures that do not typically induce MH.\n                  <\/jats:p>","DOI":"10.1096\/fj.202000403","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T01:30:04Z","timestamp":1588642204000},"page":"8721-8733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sex\u2010specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia\u2010susceptible mice"],"prefix":"10.1096","volume":"34","author":[{"given":"Jennifer M.","family":"Rutkowsky","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences School of Veterinary Medicine University of California Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trina A.","family":"Knotts","sequence":"additional","affiliation":[{"name":"Department of Molecular 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