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Three main harmful factors determine this progression: inflammation, cell death, and oxidative stress. Lipoxins and their derivatives are endogenous proresolving mediators that induce the resolution of the inflammatory process. This study aims to determine whether these mediators play a protective role in a murine model of experimental autoimmune myocarditis (EAM) by treating with the lipoxin A\n                    <jats:sub>4<\/jats:sub>\n                    analog BML\u2010111. We observed that EAM mice presented extensive infiltration areas that correlated with higher levels of inflammatory and cardiac damage markers. Both parameters were significantly reduced in BML\u2010treated EAM mice. Consistently, cardiac dysfunction, hypertrophy, and emerging fibrosis detected in EAM mice was prevented by BML\u2010111 treatment. At the molecular level, we demonstrated that treatment with BML\u2010111 hampered apoptosis and oxidative stress induction by EAM. Moreover, both in vivo and in vitro studies revealed that these beneficial effects were mediated by activation of Nrf2 pathway through CaMKK2\u2010AMPK\u03b1 kinase pathway. Altogether, our data indicate that treatment with the lipoxin derivative BML\u2010111 effectively alleviates EAM outcome and prevents cardiac dysfunction, thus, underscoring the therapeutic potential of lipoxins and their derivatives to treat myocarditis and other inflammatory cardiovascular diseases.\n                  <\/jats:p>","DOI":"10.1096\/fj.202000611r","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T14:17:37Z","timestamp":1596032257000},"page":"10531-10546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["BML\u2010111 treatment prevents cardiac apoptosis and oxidative stress in a mouse model of autoimmune myocarditis"],"prefix":"10.1096","volume":"34","author":[{"given":"Rafael I.","family":"Ja\u00e9n","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas Alberto Sols (Centro Mixto CSIC\u2010UAM) Madrid Spain"},{"name":"CIBER de 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