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By describing the life cycle of the newly emergent coronavirus, SARS\u2010CoV\u20102, in light of emerging data on the therapeutic efficacy of various repurposed antimicrobials undergoing testing against the virus, we highlight in this review a possible mechanistic convergence between some of these tested compounds. Specifically, we propose that the lysosomotropic effects of hydroxychloroquine and several other drugs undergoing testing may be responsible for their demonstrated in vitro antiviral activities against COVID\u201019. Moreover, we propose that Niemann\u2010Pick disease type C (NPC), a lysosomal storage disorder, may provide new insights into potential future therapeutic targets for SARS\u2010CoV\u20102, by highlighting key established features of the disorder that together result in an \u201cunfavorable\u201d host cellular environment that may interfere with viral propagation. Our reasoning evolves from previous biochemical and cell biology findings related to NPC, coupled with the rapidly evolving data on COVID\u201019. Our overall aim is to suggest that pharmacological interventions targeting lysosomal function in general, and those particularly capable of reversibly inducing transient NPC\u2010like cellular and biochemical phenotypes, constitute plausible mechanisms that could be used to therapeutically target COVID\u201019.<\/jats:p>","DOI":"10.1096\/fj.202000654r","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T04:58:35Z","timestamp":1588654715000},"page":"7253-7264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["The lysosome: A potential juncture between SARS\u2010CoV\u20102 infectivity and Niemann\u2010Pick disease\u00a0type C, with therapeutic implications"],"prefix":"10.1096","volume":"34","author":[{"given":"Rami A.","family":"Ballout","sequence":"first","affiliation":[{"name":"Lipoprotein Metabolism Section Translational Vascular Medicine Branch National Heart, Lung and Blood Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitri","family":"Sviridov","sequence":"additional","affiliation":[{"name":"Lipoproteins and Atherosclerosis Laboratory Baker Heart and Diabetes Institute Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Bukrinsky","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Tropical Medicine School of Medicine and Health Sciences The George Washington University Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan T.","family":"Remaley","sequence":"additional","affiliation":[{"name":"Lipoprotein Metabolism Section Translational Vascular Medicine Branch National Heart, Lung and Blood Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"issue":"8","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu NA","year":"2020","journal-title":"N Engl J Med"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(20)30129\u20108"},{"issue":"3","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3390\/v12030254","article-title":"Preliminary identification of potential vaccine targets for the COVID\u201019 coronavirus (SARS\u2010CoV\u20102) based on SARS\u2010CoV immunological studies","volume":"12","author":"Ahmed SF","year":"2020","journal-title":"Viruses"},{"issue":"6965","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin\u2010converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"Li W","year":"2003","journal-title":"Nature"},{"issue":"2","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/path.1570","article-title":"Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. 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