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Long\u2010term studies of immunity to pathogenic amyloid\u2010\u03b2 (A\u03b2) in LOAD are lacking. Innate immunity of LOAD patients is malfunctioning in phagocytosis and degradation of A\u03b2 and LOAD patients\u2019 macrophage transcriptome and metabolome are deregulated. We previously showed omega\u20103 fatty acid (\u03c9\u20103)\u2010mediated repair of unfolded protein response and here we show much broader transcriptomic effects. \u03c9\u20103 treatment in vitro and \u03c9\u20103 supplementation by the drink Smartfish (SMF) in vivo increased the transcripts of the genes and pathways of immunity, glycolysis, tricarboxylic acid cycle, OX\u2010PHOS, nicotinamide dinucleotide (NAD\n                    <jats:sup>+<\/jats:sup>\n                    ) synthesis, and reversed the defects in A\u03b2 phagocytosis. In both peripheral blood mononuclear cells (PBMC) and macrophages, \u03c9\u20103 increased ATP\u2010linked oxygen consumption rate (OCR) and \u03c9\u20103 with carnitine was superior to \u03c9\u20103. \u03c9\u20103 treatment in vitro and supplementation by the \u03c9\u20103 drink SMF in vivo rescued macrophage phagocytosis when glycolysis or glycosylation were blocked. \u03c9\u20103 provide flexible energy for immune clearance of the brain throughout the diurnal cycle, even in hypo\u2010 or hyper\u2010glycemia. In certain LOAD patients, \u03c9\u20103 may delay progression to dementia.\n                  <\/jats:p>","DOI":"10.1096\/fj.202000669rr","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T14:17:13Z","timestamp":1596032233000},"page":"9982-9994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Omega\u20103 fatty acids increase OXPHOS energy for immune therapy of Alzheimer disease patients"],"prefix":"10.1096","volume":"34","author":[{"given":"Yik Chai Charles","family":"Lau","sequence":"first","affiliation":[{"name":"Division of Oral Biology and Oral Medicine UCLA School of Dentistry and Medicine Los Angeles CA USA"},{"name":"Department of Molecular, Cell, and Developmental Biology UCLA School of Life Sciences Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica 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