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We performed a comparative microarray of the embryonic distal hindgut of wild\u2010type and\n                    <jats:italic>\n                      EdnrB\n                      <jats:sup>NCC\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice that model HSCR and identified laminin\u2010\u03b21 as upregulated in\n                    <jats:italic>\n                      EdnrB\n                      <jats:sup>NCC\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    colon. We identified decreased expression of 37\/67\u00a0kDa laminin receptor (LAMR), which binds laminin\u2010\u03b21, in human HSCR myenteric plexus and\n                    <jats:italic>\n                      EdnrB\n                      <jats:sup>NCC\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    NCC. Using a combination of in vitro gut slice cultures and ex vivo organ cultures, we determined the mechanistic role of LAMR in NCC migration. We found that enteric NCC express LAMR, which is downregulated in human and murine HSCR. Binding of LAMR by the laminin\u2010\u03b21 analog YIGSR promotes NCC migration. Silencing of LAMR abrogated these effects. Finally, applying YIGSR to E13.5\n                    <jats:italic>\n                      EdnrB\n                      <jats:sup>NCC\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    colon explants resulted in 80%\u2010100% colonization of the hindgut. This study adds LAMR to the large list of receptors through which NCC interact with their environment during ENS development. These results should be used to inform ongoing integrative, regenerative medicine approaches to HSCR.\n                  <\/jats:p>","DOI":"10.1096\/fj.202000699r","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T14:14:31Z","timestamp":1596032071000},"page":"10931-10947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["37\/67\u2010laminin receptor facilitates neural crest cell migration during enteric nervous system development"],"prefix":"10.1096","volume":"34","author":[{"given":"Ming","family":"Fu","sequence":"first","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery University of Tennessee Health Sciences Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Barlow\u2010Anacker","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin School of Medicine and 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