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In humans, this phenomenon is called high\u2010altitude anorexia and is observed in people suffering from acute mountain syndrome. The high\u2010altitude anorexia appears to be conserved in evolution and has been seen in species across the animal kingdom. However, the mechanism underlying the recovery of eating behavior after hypoxia is still not known. Here, we show that the phosphatidylinositol transfer protein PITP\u20101 is essential for the fast recovery of eating behavior after hypoxia in the nematode\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    . Unlike the neuroglobin GLB\u20105 that accelerates the recovery of eating behavior through its function in the oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    )\u2010sensing neurons, PITP\u20101 appears to act downstream, in neurons that express the\n                    <jats:italic>mod\u20101<\/jats:italic>\n                    serotonin receptor. Indeed,\n                    <jats:italic>pitp\u20101<\/jats:italic>\n                    mutants display wild\u2010type\u2010like O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010evoked\u2010calcium responses in the URX O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010sensing neuron. Intriguingly, loss\u2010of\u2010function of protein kinase C 1 (PKC\u20101) rescues\n                    <jats:italic>pitp\u20101<\/jats:italic>\n                    mutants\u2019 recovery after hypoxia. Increased diacylglycerol (DAG), which activates PKC\u20101, attenuates the recovery of wild\u2010type worms. Together, these data suggest that PITP\u20101 enables rapid recovery of eating behavior after hypoxia by limiting DAG\u2019s availability, thereby limiting PKC activity in\n                    <jats:italic>mod\u20101<\/jats:italic>\n                    \u2010expressing neurons.\n                  <\/jats:p>","DOI":"10.1096\/fj.202000704r","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T04:59:13Z","timestamp":1608872353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The phosphatidylinositol transfer protein PITP\u20101 facilitates fast recovery of eating behavior after hypoxia in the nematode\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1096","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3115-5913","authenticated-orcid":false,"given":"Zohar","family":"Abergel","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Faculty of Medicine IMRIC The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maayan","family":"Shaked","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Faculty of Medicine IMRIC The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virendra","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Faculty of Medicine IMRIC The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng\u2010Xing","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education Department of Biophysics and Molecular Physiology College of Life Science and Technology Institute of Biophysics and Biochemistry Huazhong University of Science and Technology Wuhan P.R. 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