{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:34:03Z","timestamp":1788950043909,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974186"],"award-info":[{"award-number":["81974186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671205"],"award-info":[{"award-number":["81671205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["18XD1402700"],"award-info":[{"award-number":["18XD1402700"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["YG2017MS68"],"award-info":[{"award-number":["YG2017MS68"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Many factors are involved in the process of nerve regeneration. Understanding the mechanisms regarding how these factors promote an efficient remyelination is crucial to deciphering the molecular and cellular processes required to promote nerve repair. Schwann cells (SCs) play a central role in the process of peripheral nerve repair\/regeneration. Using a model of facial nerve crush injury and repair, we identified Annexin A1 (ANXA1) as the extracellular trigger of SC proliferation and migration. ANXA1 activated formyl peptide receptor 2 (FPR2) receptors and the downstream adenosine 5\u2032\u2010monophosphate (AMP)\u2010activated protein kinase (AMPK) signaling cascade, leading to SC proliferation and migration in vitro. SCs lacking FPR2 or AMPK displayed a defect in proliferation and migration. After facial nerve injury (FNI), ANXA1 promoted the proliferation of SCs and nerve regeneration in vivo. Collectively, these data identified the ANXA1\/FPR2\/AMPK axis as an important pathway in SC proliferation and migration. ANXA1\u2010induced remyelination and SC proliferation promotes FNI regeneration.<\/jats:p>","DOI":"10.1096\/fj.202000726rrr","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T11:04:29Z","timestamp":1598612669000},"page":"13993-14005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["ANXA1 directs Schwann cells proliferation and migration to accelerate nerve regeneration through the FPR2\/AMPK pathway"],"prefix":"10.1096","volume":"34","author":[{"given":"Wenzheng","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Center for Diagnosis and Treatment of Cranial Nerve Diseases Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Center for Diagnosis and Treatment of Cranial Nerve Diseases Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Center for Diagnosis and Treatment of Cranial Nerve Diseases Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinda","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Center for Diagnosis and Treatment of Cranial Nerve Diseases Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Center for Diagnosis and Treatment of Cranial Nerve Diseases Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology First Affiliated Hospital, Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Center for Diagnosis and Treatment of Cranial Nerve Diseases Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70221-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719854446"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094337"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.227"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2470"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0941fje"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-182089"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4595"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17622-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1204-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101770"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1038\/s41598-017-03368-7","article-title":"FPR2 promotes invasion and metastasis of gastric cancer cells and predicts the prognosis of patients","volume":"7","author":"Hou XL","year":"2017","journal-title":"Sci Rep"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718817219"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25946"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141647"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-961"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2017.01.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.10.019"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23273"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124635"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109248"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.10.212"},{"key":"e_1_2_9_24_1","first-page":"1127","article-title":"Macrophage migration inhibitory factor rescues mesenchymal stem cells from doxorubicin\u2010induced senescence though the PI3K\u2010Akt signaling pathway","volume":"41","author":"Xia W","year":"2018","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_25_1","first-page":"2175","article-title":"Role of lincRNAp21 in the protective effect of macrophage inhibition factor against hypoxia\/serum deprivationinduced apoptosis in mesenchymal stem cells","volume":"42","author":"Xia W","year":"2018","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1273"},{"key":"e_1_2_9_27_1","first-page":"1747","article-title":"Different sensitivities to rocuronium of the neuromuscular junctions innervated by normal\/damaged facial nerves and somatic nerve in rats: the role of the presynaptic acetylcholine quantal release","volume":"125","author":"Chen JL","year":"2012","journal-title":"China Med J"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901596R"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2534"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-154096"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2840"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.039345"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2019.01.003"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.08.020"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-110"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20761"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270874"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.5.011303.120731"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0405206"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65831"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.03.050"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.393561"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12833"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.535674"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900871"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500733"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.11.008"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3311"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3809"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.134762"},{"key":"e_1_2_9_51_1","doi-asserted-by":"crossref","first-page":"e1800075","DOI":"10.1002\/bies.201800075","article-title":"The LKB1\u2010AMPK and mTORC1 metabolic signaling networks in schwann cells control axon integrity and myelination: assembling and upholding nerves by metabolic signaling in Schwann cells","volume":"41","author":"Beirowski B","year":"2019","journal-title":"BioEssays: News Rev Mol, Cell Develop Biol"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202000726RRR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202000726RRR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202000726RRR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:19:08Z","timestamp":1761689948000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202000726RRR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,27]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1096\/fj.202000726RRR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202000726rrr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,27]]},"assertion":[{"value":"2020-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}