{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:06:58Z","timestamp":1790122018130,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_153456"],"award-info":[{"award-number":["310030_153456"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pericytes promote vessel stability and their dysfunction causes pathologies due to blood vessel leakage. Previously, we reported that Olfactomedin\u2010like 3 (Olfml3) is a matricellular protein with proangiogenic properties. Here, we explored the role of Olfml3 in a knockout mouse model engineered to suppress this protein. The mutant mice exhibited vascular defects in pericyte coverage, suggesting that pericytes influence blood vessel formation in an Olfml3\u2010dependent manner.\n                    <jats:italic>Olfml3<\/jats:italic>\n                    \u2010deficient mice exhibited abnormalities in the vasculature causing partial lethality of embryos and neonates. Reduced pericyte coverage was observed at embryonic day 12.5 and persisted throughout development, resulting in perinatal death of 35% of\n                    <jats:italic>Olfml3<\/jats:italic>\n                    \u2010deficient mice. Cultured\n                    <jats:italic>Olfml3<\/jats:italic>\n                    \u2010deficient pericytes exhibited aberrant motility and altered pericyte association to endothelial cells. Furthermore, the proliferative response of\n                    <jats:italic>\n                      Olfml3\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    pericytes upon PDGF\u2010B stimulation was significantly diminished. Subsequent experiments revealed that intact PDGF\u2010B signaling, mediated via Olfml3 binding, is required for pericyte proliferation and activation of downstream kinase pathways. Our findings suggest a model wherein pericyte recruitment to endothelial cells requires Olfml3 to provide early instructive cue and retain PDGF\u2010B along newly formed vessels to achieve optimal angiogenesis.\n                  <\/jats:p>","DOI":"10.1096\/fj.202000751rr","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T15:27:45Z","timestamp":1601479665000},"page":"15559-15576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Olfactomedin\u2010like 3 promotes PDGF\u2010dependent pericyte proliferation and migration during embryonic blood vessel formation"],"prefix":"10.1096","volume":"34","author":[{"given":"Beat A.","family":"Imhof","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology University of Geneva Medical School Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Ballet","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Hammel","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology and Metabolism University of Geneva Medical School Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Jemelin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology University of Geneva Medical School Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Garrido\u2010Urbani","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology University of Geneva Medical School Geneva 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