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In this study, we evaluated the potential efficacy of porphyran\u2010derived oligosaccharides from\n                    <jats:italic>Porphyra yezoensis<\/jats:italic>\n                    (PYOs) in alleviating nonalcoholic fatty liver disease (NAFLD) and preliminarily clarified the underlying mechanism. NAFLD was induced by a high\u2010fat diet for six months in C57BL\/6J mice, followed by treatment with PYOs (100 or 300\u00a0mg\/kg\/d) for another six weeks. We found that PYOs reduced hepatic oxidative stress in mice with NAFLD, which plays a critical role in the occurrence and development of NAFLD. In addition, PYOs could markedly decrease lipid accumulation in liver by activating the IRS\u20101\/AKT\/GSK\u20103\u03b2 signaling pathway and the AMPK signaling pathway in mice with NAFLD. PYOs also apparently relieved the hepatic fibrosis induced by oxidative stress via downregulation of TGF\u2010\u03b2 and its related proteins, so that liver injury was markedly alleviated. Furthermore, PYOs treatment relieved cecal microbiota dysbiosis (such as increasing the relative abundance of\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    , while decreasing the\n                    <jats:italic>Helicobacter<\/jats:italic>\n                    abundance), which could alleviate oxidative stress, inflammation, and lipid metabolism, and protect the liver to a certain degree. In summary, PYOs treatment remarkably improved NAFLD via a specific molecular mechanism and reshaped the cecal microbiota.\n                  <\/jats:p>","DOI":"10.1096\/fj.202000763rrr","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T02:38:50Z","timestamp":1620182330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Porphyran\u2010derived oligosaccharides alleviate NAFLD and related cecal microbiota dysbiosis in mice"],"prefix":"10.1096","volume":"35","author":[{"given":"Xueliang","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Drugs of Ministry of Education Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology School of Medicine and Pharmacy Ocean University of China Qingdao China"},{"name":"Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology (Qingdao) Qingdao 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