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Organ coefficients of the liver, stomach, and kidney were found to be decreased. H&amp;E staining revealed overt lesions in the pancreas, liver, kidney, esophagus, duodenum, and ileum of RCO\u2010treated mice. Immunohistochemistry showed significant DNA damage in the duodenum and ileum and apoptosis in the lungs of the RCO\u2010treated mice. Immunoblotting showed elevated levels of \u03b3\u2010H2AX, Bcl\u20102\/Bax, TNF\u03b1, cleaved Caspase\u20103 and poly ADP\u2010ribose polymerase (PARP). Increased levels of lactate dehydrogenase (LDH) and decreased levels of succinate dehydrogenase (SDH) were also detected. These findings suggest that long\u2010term consumption of RCO produces various toxicities in mice with important implications for humans. DNA damage followed by mitochondria\u2010associated apoptosis, and necrosis is likely to contribute to the toxicities.<\/jats:p>","DOI":"10.1096\/fj.202000825r","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T15:00:33Z","timestamp":1605798033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term consumption of recycled cooking oil induces cell death and tissue damage"],"prefix":"10.1096","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8605-3354","authenticated-orcid":false,"given":"Shudong","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Medicine Nantong University Nantong China"},{"name":"Department of Biochemistry and Molecular Biology School of Life Sciences Central South University Changsha 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