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SHP2 is involved in gastrointestinal (GI) epithelium development and homeostasis, but the underlying mechanisms remain elusive. While studying SHP2\u2019s role in skeletal development, we made osteoblast\u2010specific SHP2 deficient mice using\n                    <jats:italic>Osterix (Osx)\u2010Cre<\/jats:italic>\n                    as a driver to excise\n                    <jats:italic>Ptpn11<\/jats:italic>\n                    floxed alleles. Phenotypic characterization of these SHP2 mutants unexpectedly revealed a critical role of SHP2 in GI biology. Mice lacking SHP2 in\n                    <jats:italic>Osx<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    cells developed a fatal GI pathology with dramatic villus hypoplasia. OSTERIX, an OB\u2010specific zinc finger\u2010containing transcription factor is for the first time found to be expressed in GI crypt cells, and SHP2 expression in the crypt\n                    <jats:italic>Osx+<\/jats:italic>\n                    cells is critical for self\u2010renewal and proliferation. Further, immunostaining revealed the colocalization of OSTERIX with OLFM4 and LGR5, two\n                    <jats:italic>bona fide<\/jats:italic>\n                    GI stem cell markers, at the crypt cells. Furthermore, OSTERIX expression is found to be associated with GI malignancies. Knockdown of SHP2 expression had no apparent influence on the relative numbers of enterocytes, goblet cells or Paneth cells. Given SHP2\u2019s key regulatory role in OB differentiation, our studies suggest that OSTERIX and SHP2 are indispensable for gut homeostasis, analogous to SOX9\u2019s dual role as a master regulator of cartilage and an important regulator of crypt stem cell biology. Our findings also provide a foundation for new avenues of inquiry into GI stem cell biology and of OSTERIX\u2019s therapeutic and diagnostic potential.\n                  <\/jats:p>","DOI":"10.1096\/fj.202001091r","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T15:52:54Z","timestamp":1604937174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["RETRACTED: SHP2 regulates the development of intestinal epithelium by modifying OSTERIX\n                    <sup>+<\/sup>\n                    crypt stem cell self\u2010renewal and proliferation"],"prefix":"10.1096","volume":"35","author":[{"given":"Lijun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedics Brown University Alpert Medical School and Rhode Island Hospital Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas 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