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Global knockouts of the\n                    <jats:italic>at<\/jats:italic>\n                    RA clearing enzymes Cyp26a1 or Cyp26b1 are embryonic lethal. In adult rodents, inhibition of Cyp26a1 and Cyp26b1 increases\n                    <jats:italic>at<\/jats:italic>\n                    RA concentrations and signaling. However, postnatal knockout of Cyp26a1 does not cause a severe phenotype. We hypothesized that Cyp26b1 is the main\n                    <jats:italic>at<\/jats:italic>\n                    RA clearing Cyp in postnatal mammals. This hypothesis was tested by generating tamoxifen\u2010inducible knockout mouse models of Cyp26b1 alone or with Cyp26a1. Both mouse models showed dermatitis, blepharitis, and splenomegaly. Histology showed infiltration of inflammatory cells including neutrophils and T lymphocytes into the skin and hyperkeratosis\/hyperplasia of the nonglandular stomach. The mice lacking both Cyp26a1 and Cyp26b1 also had a reduced lifespan, failed to gain weight, and showed fat atrophy. There were significant changes in vitamin A homeostasis. Postnatal knockout of Cyp26b1 resulted in increased\n                    <jats:italic>at<\/jats:italic>\n                    RA concentrations in the skin while the postnatal knockout of both Cyp26a1 and Cyp26b1 resulted in increased\n                    <jats:italic>at<\/jats:italic>\n                    RA concentrations in the liver, serum, skin, spleen, and intestines. This study demonstrates the paramount role of Cyp26b1 in regulating retinoid homeostasis in postnatal life.\n                  <\/jats:p>","DOI":"10.1096\/fj.202001734r","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T14:27:22Z","timestamp":1603722442000},"page":"15788-15804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice"],"prefix":"10.1096","volume":"34","author":[{"given":"Jessica M.","family":"Snyder","sequence":"first","affiliation":[{"name":"Department of Comparative Medicine School of Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy University of 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