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Alterations in MR signaling pathway lead to renal dysfunction, including chronic kidney disease and renal fibrosis, that can be prevented or treated with mineralocorticoid receptor antagonists (MRAs). Here, we used RNA\u2010Sequencing to analyze effects of two MRAs, spironolactone and finerenone, on the aldosterone\u2010induced transcriptome of a human renal cell line stably expressing the MR. Bioinformatics analysis of the data set reveals the identity of hundreds of genes induced or repressed by aldosterone. Their regulation is modulated in a time\u2010dependent manner and, for the induced genes, depends on the aldosterone\u2010driven direct binding of the MR onto its genomic targets that we have previously characterized. Although both MRAs block aldosterone\u2010induced as well as aldosterone\u2010repressed genes qualitatively similarly, finerenone has a quantitatively more efficient antagonism on some aldosterone\u2010induced genes. Our data provide the first complete transcriptome for aldosterone on a human renal cell line and identifies pro\u2010inflammatory markers (\n                    <jats:italic>IL6, IL11, CCL7,<\/jats:italic>\n                    and\n                    <jats:italic>CXCL8<\/jats:italic>\n                    ) as aldosterone\u2010repressed genes.\n                  <\/jats:p>","DOI":"10.1096\/fj.202002043rr","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T14:11:37Z","timestamp":1610547097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Antagonistic effects of finerenone and spironolactone on the aldosterone\u2010regulated transcriptome of human kidney cells"],"prefix":"10.1096","volume":"35","author":[{"given":"Florian","family":"Le Billan","sequence":"first","affiliation":[{"name":"Physiologie et Physiopathologie Endocriniennes Inserm Universit\u00e9 Paris\u2010Saclay Le 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