{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:35:06Z","timestamp":1791758106410,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:00:00Z","timestamp":1606003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD084478"],"award-info":[{"award-number":["R01HD084478"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Though endometriosis and infertility are clearly associated, the pathophysiological mechanism remains unclear. Previous work has linked endometrial ARID1A loss to endometriosis\u2010related endometrial non\u2010receptivity. Here, we show in mice that ARID1A binds and regulates transcription of the\n                    <jats:italic>Foxa2<\/jats:italic>\n                    gene required for endometrial gland function. Uterine\u2010specific deletion of\n                    <jats:italic>Arid1a<\/jats:italic>\n                    compromises gland development and diminishes\n                    <jats:italic>Foxa2<\/jats:italic>\n                    and\n                    <jats:italic>Lif<\/jats:italic>\n                    expression. Deletion of\n                    <jats:italic>Arid1a<\/jats:italic>\n                    with Ltf\u2010iCre in the adult mouse endometrial epithelium preserves the gland development while still compromising the gland function. Mice lacking endometrial epithelial\n                    <jats:italic>Arid1a<\/jats:italic>\n                    are severely sub\u2010fertile due to defects in implantation, decidualization, and endometrial receptivity from disruption of the LIF\u2010STAT3\u2010EGR1 pathway. FOXA2 is also reduced in the endometrium of women with endometriosis in correlation with diminished ARID1A, and both ARID1A and FOXA2 are reduced in nonhuman primates induced with endometriosis. Our findings describe a role for ARID1A in the endometrial epithelium supporting early pregnancy establishment through the maintenance of gland function.\n                  <\/jats:p>","DOI":"10.1096\/fj.202002178r","type":"journal-article","created":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T06:05:10Z","timestamp":1606025110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment"],"prefix":"10.1096","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6597-4506","authenticated-orcid":false,"given":"Ryan M.","family":"Marquardt","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Biology Michigan State University Grand Rapids MI USA"},{"name":"Cell and Molecular Biology Program Michigan State University East Lansing MI 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Michigan State University Grand Rapids MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asgerally T.","family":"Fazleabas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Biology Michigan State University Grand Rapids MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5205-4495","authenticated-orcid":false,"given":"Steven L.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Lessey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Wake Forest Baptist Health Winston\u2010Salem NC 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