{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:26:38Z","timestamp":1761675998413,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1002804"],"award-info":[{"award-number":["2018YFC1002804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Repeated implantation failure (RIF) is a major problem that limits the pregnancy rate associated with assisted reproductive technology. However, the pathogenesis of RIF is still unknown. Recently, the expression levels of circular RNAs (circRNAs) were profiled in the endometrial tissues of patients with RIF. However, the exact role of circRNAs in RIF remains unclear. In our study, we found that\n                    <jats:italic>circFAM120A<\/jats:italic>\n                    levels were significantly down\u2010regulated in the endometrium at the window of implantation in RIF patients compared with non\u2010RIF controls. The suppression of\n                    <jats:italic>circFAM120A<\/jats:italic>\n                    expression inhibited decidualization in human endometrial stromal cells (hESCs). Furthermore, RNA\u2010seq analysis after\n                    <jats:italic>circFAM120A<\/jats:italic>\n                    knockdown revealed\n                    <jats:italic>ABHD5<\/jats:italic>\n                    as a potential downstream target gene of\n                    <jats:italic>circFAM120A<\/jats:italic>\n                    . As expected, down\u2010regulating\n                    <jats:italic>ABHD5<\/jats:italic>\n                    in hESCs also inhibited decidualization. Using the starBase and TargetScan databases, we predicted that\n                    <jats:italic>miR\u201029<\/jats:italic>\n                    may interact with\n                    <jats:italic>ABHD5<\/jats:italic>\n                    , based on nucleotide sequence matching. Luciferase reporter assay showed that\n                    <jats:italic>miR\u201029<\/jats:italic>\n                    bound to the 3\u2032 UTR of\n                    <jats:italic>ABHD5<\/jats:italic>\n                    at the predicted complementary sites. Moreover,\n                    <jats:italic>miR\u201029<\/jats:italic>\n                    mimics efficiently reduced\n                    <jats:italic>ABHD5<\/jats:italic>\n                    expression levels and suppressed the decidualization process, whereas a\n                    <jats:italic>miR\u201029<\/jats:italic>\n                    inhibitor partly rescued\n                    <jats:italic>ABHD5<\/jats:italic>\n                    mRNA expression level and decidualization reduced by the knockdown of\n                    <jats:italic>circFAM120A<\/jats:italic>\n                    . Therefore,\n                    <jats:italic>circFAM120A<\/jats:italic>\n                    modulated decidualization in RIF through the\n                    <jats:italic>miR\u201029<\/jats:italic>\n                    \/\n                    <jats:italic>ABHD5<\/jats:italic>\n                    axis.\n                  <\/jats:p>","DOI":"10.1096\/fj.202002298rr","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T15:17:41Z","timestamp":1630077461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>circFAM120A<\/i>\n                    participates in repeated implantation failure by regulating decidualization via the\n                    <i>miR\u201029<\/i>\n                    \/\n                    <i>ABHD5<\/i>\n                    axis"],"prefix":"10.1096","volume":"35","author":[{"given":"Tingting","family":"Zhou","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine Cheeloo College of Medicine Shandong University Jinan China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianxiang","family":"Ni","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Cheeloo College of Medicine Shandong University Jinan China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Cheeloo College of Medicine Shandong University Jinan China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Cheeloo College of Medicine Shandong University Jinan China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7110-8698","authenticated-orcid":false,"given":"Junhao","family":"Yan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Cheeloo College of Medicine Shandong University Jinan China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi\u2010Jiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Cheeloo College of Medicine Shandong University Jinan China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv016"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn042"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.03.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.08.011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.05.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep303"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep193"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366\u20106999.170258"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906103402304"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2014\u20101045"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt048"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.99"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.23.090506.123406"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11928"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010018\u20101326\u2010y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes9120574"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.25081"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der255"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.144056"},{"issue":"1","key":"e_1_2_9_21_1","first-page":"1","article-title":"Biological functions of circular RNAs and their roles in occurrence of reproduction and gynecological diseases","volume":"11","author":"Liu KS","year":"2019","journal-title":"Am J Transl Res"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484887"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010019\u20100158\u20107"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz382"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27675"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17307"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.08.79"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e328346230e"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42589"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.012841"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15696"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366\u20106999.200550"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2018.12.011"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.081059"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.062"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7323"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE\u201019\u20100127"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010019\u201002601\u20108"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010258"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa070"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010287"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202002298RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202002298RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202002298RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:04:30Z","timestamp":1761674670000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202002298RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,27]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1096\/fj.202002298RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202002298rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"type":"print","value":"0892-6638"},{"type":"electronic","value":"1530-6860"}],"subject":[],"published":{"date-parts":[[2021,8,27]]},"assertion":[{"value":"2020-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e21872"}}