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Currently, the race is on to identify pharmaceutical molecules or combinations of molecules able to prevent or reduce the insurgence and\/or progression of infectivity. Attempts to substitute antibiotics with antimicrobial peptides have, thus far, met with little success against multidrug\u2010resistant (MDR) bacterial strains. During the last decade, we designed and studied the activity and features of human \u03b2\u2010defensin analogs, which are salt\u2010resistant, and hence active also under high salt concentrations as, for instance, in cystic fibrosis. Herein, we describe the design, synthesis, and major features of a new 21 aa long molecule, peptide \u03b32. The latter derives from the \u03b3\u2010core of the \u03b2\u2010defensin natural molecules, a small fragment of these molecules still bearing high antibacterial activity. 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In conclusion, peptide \u03b32 is a promising new weapon also in the battle against intractable infectious diseases.<\/jats:p>","DOI":"10.1096\/fj.202002330rr","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T03:22:09Z","timestamp":1637896929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A novel smaller \u03b2\u2010defensin\u2010derived peptide is active against multidrug\u2010resistant bacterial strains"],"prefix":"10.1096","volume":"35","author":[{"given":"Roberta","family":"Colicchio","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersilia","family":"Nigro","sequence":"additional","affiliation":[{"name":"CEINGE, Biotecnologie Avanzate s.c.ar.l. 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