{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T16:57:15Z","timestamp":1772384235683,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["4111"],"award-info":[{"award-number":["4111"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Visceral leishmaniasis (VL) is a debilitating human pathogenesis in which the body's immune functions are severely compromised. Various subsets of T cells, including Th17 cells are important regulators of immune responses observed in various pathologies. The role of Th17 cells and its correlation with immuno\u2010regulatory cytokines are however not well understood in human VL. Herein we studied how IL\u201017 is associated with the progression of\n                    <jats:italic>Leishmania donovani<\/jats:italic>\n                    infection using murine model of VL. We found induction of a strong IL\u201017 response at the early phase of infection which progressively reduced to basal level during chronic VL. The mechanistic study of this behavior was found to be linked with the role of regulatory T cells (CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>+<\/jats:sup>\n                    T cells) that suppresses the proliferation of the Th17 cell population. Moreover, TGF\u2010\u03b2 and IL\u201035 derived from CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>+<\/jats:sup>\n                    T cells are the key mediators for the downregulation of IL\u201017 during chronic VL. Thus, this study points to an antagonistic effect of Tregs and Th17 cells that can be used for designing better therapeutic and preventive strategies against leishmaniasis.\n                  <\/jats:p>","DOI":"10.1096\/fj.202002356rr","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T13:18:15Z","timestamp":1628774295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effector functions of Th17 cells are regulated by IL\u201035 and TGF\u2010\u03b2 in visceral leishmaniasis"],"prefix":"10.1096","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3078-200X","authenticated-orcid":false,"given":"Mohammad","family":"Asad","sequence":"first","affiliation":[{"name":"Infectious Diseases and Immunology Division Indian Institute of Chemical Biology Kolkata India"},{"name":"Department of Medicine Albert Einstein College of Medicine\/ Montefiore Medical Center 1300 Morris Park Avenue Bronx NY 10461 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdus","family":"Sabur","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Immunology Division Indian Institute of Chemical Biology Kolkata India"},{"name":"Raiganj Surendranath Mahavidyalaya Affiliated to University of Gour Banga Uttar Dinajpur Raiganj West Bengal 733134 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd","family":"Kamran","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Immunology Division Indian Institute of Chemical Biology Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md.","family":"Shadab","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Immunology Division Indian Institute of Chemical Biology Kolkata India"},{"name":"Department of Pediatrics University of Rochester Medical Center 601 Elmwood Avenue Rochester NY 14642 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