{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:04:46Z","timestamp":1773432286765,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2016\u201001538"],"award-info":[{"award-number":["2016\u201001538"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CBRG\/0107\/2016"],"award-info":[{"award-number":["NMRC\/CBRG\/0107\/2016"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Life\u2010style change and anti\u2010inflammatory interventions have only transient effects in obesity. It is not clear how benefits obtained by these treatments can be maintained longer term, especially during sustained high caloric intake. Constitutive ablation of the activin receptor ALK7 in adipose tissue enhances catecholamine signaling and lipolysis in adipocytes, and protects mice from diet\u2010induced obesity. Here, we investigated the consequences of conditional ALK7 ablation in adipocytes of adult mice with pre\u2010existing obesity. Although ALK7 deletion had little effect on its own, it synergized strongly with a transient switch to low\u2010fat diet (life\u2010style change) or anti\u2010inflammatory treatment (Na\u2010salicylate), resulting in enhanced lipolysis, increased energy expenditure, and reduced adipose tissue mass and body weight gain, even under sustained high caloric intake. By themselves, diet\u2010switch and salicylate had only a temporary effect on weight gain. Mechanistically, combination of ALK7 ablation with either treatment strongly enhanced the levels of \u03b23\u2010AR, the main adrenergic receptor for catecholamine stimulation of lipolysis, and C\/EBP\u03b1, an upstream regulator of \u03b23\u2010AR expression. These results suggest that inhibition of ALK7 can be combined with simple interventions to produce longer\u2010lasting benefits in obesity.<\/jats:p>","DOI":"10.1096\/fj.202002785rr","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T13:20:54Z","timestamp":1625923254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sustained anti\u2010obesity effects of life\u2010style change and anti\u2010inflammatory interventions after conditional inactivation of the activin receptor ALK7"],"prefix":"10.1096","volume":"35","author":[{"given":"Raj Kamal","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Physiology and Life Sciences Institute National University of Singapore Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ee\u2010Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology and Life Sciences Institute National University of Singapore Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Physiology and Life Sciences Institute National University of Singapore Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"New Chih","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Life Sciences Institute National University of Singapore Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos F.","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Physiology and Life Sciences Institute National University of Singapore Singapore Singapore"},{"name":"Peking\u2010Tsinghua Center for Life Sciences Peking University School of Life Sciences Beijing China"},{"name":"PKU\u2010IDG\/McGovern Institute for Brain Research Peking University School of Life Sciences Beijing China"},{"name":"Chinese Institute for Brain Research Beijing China"},{"name":"Department of Neuroscience Karolinska Institute Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0148-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21538"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20027"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1338"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061620"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"231","article-title":"Salsalate, an old, inexpensive drug with potential new indications: a review of the evidence from 3 recent 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