{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:37:22Z","timestamp":1774269442711,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB38010400"],"award-info":[{"award-number":["XDB38010400"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Novel coronary pneumonia (COVID\u201019) is a respiratory distress syndrome caused by a new type of coronavirus. Understanding the genetic basis of susceptibility and prognosis to COVID\u201019 is of great significance to disease prevention, molecular typing, prognosis, and treatment. However, so far, there have been only two genome\u2010wide association studies (GWASs) on the susceptibility of COVID\u201019. Starting with these reported DNA variants, we found the genes regulated by these variants through cis\u2010eQTL and cis\u2010meQTL acting. We further did a series of bioinformatics analysis on these potential risk genes. The analysis shows that the genetic variants on\n                    <jats:italic>EHF<\/jats:italic>\n                    regulate the expression of its neighbor\n                    <jats:italic>CAT<\/jats:italic>\n                    gene via cis\u2010eQTL. There was significant evidence that CAT and the SARS\u2010CoV\u20102\u2010related S protein binding protein ACE2 interact with each other. Intracellular localization results showed that\n                    <jats:italic>CAT<\/jats:italic>\n                    and\n                    <jats:italic>ACE2<\/jats:italic>\n                    proteins both exists in the cell membrane and extracellular area and their interaction could have an impact on the cell invasion ability of S protein. In addition, the expression of these three genes showed a significant positive correlation in the lungs. Based on these results, we propose that\n                    <jats:italic>CAT<\/jats:italic>\n                    plays a crucial intermediary role in binding effectiveness of\n                    <jats:italic>ACE2<\/jats:italic>\n                    , thereby affecting the susceptibility to COVID\u201019.\n                  <\/jats:p>","DOI":"10.1096\/fj.202100008","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T10:50:54Z","timestamp":1615546254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evidence for\n                    <i>CAT<\/i>\n                    gene being functionally involved in the susceptibility of COVID\u201019"],"prefix":"10.1096","volume":"35","author":[{"given":"Yu","family":"Qian","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics, Chinese Academy of Sciences Beijing China"},{"name":"University of Chinese Academy of Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics, Chinese Academy of Sciences Beijing China"},{"name":"University of Chinese Academy of Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxuan","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics, Chinese Academy of Sciences Beijing China"},{"name":"University of Chinese Academy of Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Yuan","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics, Chinese Academy of Sciences Beijing China"},{"name":"University of Chinese Academy of Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjie","family":"Ma","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics, Chinese Academy of Sciences Beijing China"},{"name":"University of Chinese Academy of Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics, Chinese Academy of Sciences Beijing China"},{"name":"University of Chinese Academy of Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics, Chinese Academy of Sciences Beijing China"},{"name":"University of Chinese Academy of Sciences Beijing China"},{"name":"China National Center for Bioinformation Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.02.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2000083"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2020283"},{"key":"e_1_2_8_7_1","article-title":"The landscape of host genetic factors involved in infection to common viruses and SARS\u2010CoV\u20102","author":"Kachuri L","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2756"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12228-z"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky814"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0842-7"},{"key":"e_1_2_8_12_1","first-page":"851","article-title":"An immunohistochemical analysis of antioxidant and glutathione S\u2010transferase enzyme levels in normal and neoplastic human lung","volume":"11","author":"Coursin DB","year":"1996","journal-title":"Histol Histopathol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.9.5587"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00249.2010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-183"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00296.2005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004901"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq537"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15562-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1099"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku989"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04169-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2653"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202100008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202100008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202100008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:19:53Z","timestamp":1761671993000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202100008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,12]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1096\/fj.202100008"],"URL":"https:\/\/doi.org\/10.1096\/fj.202100008","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,12]]},"assertion":[{"value":"2021-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e21384"}}