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We used cysteine\u2010specific isotopic coded affinity tags (OxICAT) and gel\u2010free mass spectrometry analysis to investigate the cysteine Ox\u2010PTMs profile in the proteome of both\n                    <jats:italic>plantaris<\/jats:italic>\n                    (glycolytic) and\n                    <jats:italic>soleus<\/jats:italic>\n                    (oxidative) muscles in tumor\u2010bearing and control rats. Histological analysis revealed muscle atrophy in type II fibers in\n                    <jats:italic>plantaris<\/jats:italic>\n                    muscle, with no changes in\n                    <jats:italic>plantaris<\/jats:italic>\n                    type I fibers and no differences in both\n                    <jats:italic>soleus<\/jats:italic>\n                    type I and II fibers in tumor\u2010bearing rats when compared to healthy controls. Tumor progression altered the Ox\u2010PTMs profile in both\n                    <jats:italic>plantaris<\/jats:italic>\n                    and\n                    <jats:italic>soleus<\/jats:italic>\n                    . However, pathway analysis including the differentially oxidized proteins revealed tricarboxylic acid cycle and oxidative phosphorylation as main affected pathways in\n                    <jats:italic>plantaris<\/jats:italic>\n                    muscle from tumor\u2010bearing rats, while the same analysis did not show main metabolic pathways affected in the\n                    <jats:italic>soleus<\/jats:italic>\n                    muscle. In addition, cancer progression affected several metabolic parameters such as ATP levels and markers of oxidative stress associated with muscle atrophy in\n                    <jats:italic>plantaris<\/jats:italic>\n                    muscle, but not in\n                    <jats:italic>soleus<\/jats:italic>\n                    . However, isolated\n                    <jats:italic>soleus<\/jats:italic>\n                    from tumor\u2010bearing rats had a reduced force production capacity when compared to controls. These novel findings demonstrate that tumor\u2010bearing rats have severe muscle atrophy exclusively in glycolytic fibers. Cancer progression is associated with cysteine Ox\u2010PTMs in the skeletal muscle, but these modifications affect different pathways in a glycolytic muscle compared to an oxidative muscle, indicating that intrinsic muscle oxidative capacity determines the response to cancer cachectic effects.\n                  <\/jats:p>","DOI":"10.1096\/fj.202100263r","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T08:40:03Z","timestamp":1623487203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cancer\u2010induced muscle atrophy is determined by intrinsic muscle oxidative capacity"],"prefix":"10.1096","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-9689","authenticated-orcid":false,"given":"Christiano R. 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