{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:51:55Z","timestamp":1793479915241,"version":"4.5.0"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR068972"],"award-info":[{"award-number":["AR068972"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR076758"],"award-info":[{"award-number":["AR076758"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR049192"],"award-info":[{"award-number":["AR049192"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR074992"],"award-info":[{"award-number":["AR074992"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR072623"],"award-info":[{"award-number":["AR072623"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011781","name":"Shriners Hospitals for Children","doi-asserted-by":"publisher","award":["85160"],"award-info":[{"award-number":["85160"]}],"id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Overwhelming evidence indicates that excessive stimulation of innate immune receptors of the NOD\u2010like receptor (NLR) family causes significant damage to multiple tissues, yet the role of these proteins in bone metabolism is not well known. Here, we studied the interaction between the NLRP3 and NLRC4 inflammasomes in bone homeostasis and disease. We found that loss of NLRP3 or NLRC4 inflammasome attenuated osteoclast differentiation in vitro. At the tissue level, lack of NLRP3, or NLRC4 to a lesser extent, resulted in higher baseline bone mass compared to wild\u2010type (WT) mice, and conferred protection against LPS\u2010induced inflammatory osteolysis. Bone mass accrual in mutant mice correlated with lower serum IL\u20101\u03b2 levels in vivo. Unexpectedly, the phenotype of\n                    <jats:italic>Nlrp3<\/jats:italic>\n                    \u2010deficient mice was reversed upon loss of NLRC4 as bone mass was comparable between WT mice and\n                    <jats:italic>Nlrp3;Nlrc4<\/jats:italic>\n                    knockout mice. Thus, although bone homeostasis is perturbed to various degrees by the lack of NLRP3 or NLRC4, this tissue appears to function normally upon compound loss of the inflammasomes assembled by these receptors.\n                  <\/jats:p>","DOI":"10.1096\/fj.202100767rr","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T13:18:11Z","timestamp":1628774291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Actions of the NLRP3 and NLRC4 inflammasomes overlap in bone resorption"],"prefix":"10.1096","volume":"35","author":[{"given":"Yael","family":"Alippe","sequence":"first","affiliation":[{"name":"Division of Bone and Mineral Diseases Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Kress","sequence":"additional","affiliation":[{"name":"Division of Bone and Mineral Diseases Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biancamaria","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Bone and Mineral Diseases Washington University School of Medicine St. Louis MO USA"},{"name":"Department of Spine Surgery Honghui Hospital Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Bone and Mineral Diseases Washington University School of Medicine St. Louis MO USA"},{"name":"Department of Spine Surgery Honghui Hospital Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Bone and Mineral Diseases Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Division of Bone and Mineral Diseases Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Abu\u2010Amer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Washington University School of Medicine St. Louis MO USA"},{"name":"Shriners Hospital for Children St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Mbalaviele","sequence":"additional","affiliation":[{"name":"Division of Bone and Mineral Diseases Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2873"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00398"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.03.030"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.02.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.5.3574"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.9.4559"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040689"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.7.1211"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10688"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.170"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3089"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150237"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.691013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.046"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747404"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.10.011"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.013"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.139"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18629"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.01.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1703"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121198"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2014.08.011"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12534"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100257"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402911111"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301581"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1403252111"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1403477111"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1770-6"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1548-x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191644"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035979"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.09.010"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2019.10.004"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-264804"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520933533"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64685-y"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12973"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22190"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000807"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.071002"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2008.07.016"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93356"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0358-0"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05033-5"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07014-0"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4267"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20141091"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402573"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131702"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.8.1477"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11351"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2017.03.009"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.6.1044"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.MCHD\u20100011\u20102015"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00753-4"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-007-0834-0"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.052"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12285"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9656270"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.155"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30162"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132234"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006502"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21998-3"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202100767RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202100767RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202100767RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:06:14Z","timestamp":1761674774000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202100767RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,12]]},"references-count":67,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1096\/fj.202100767RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202100767rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,12]]},"assertion":[{"value":"2021-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e21837"}}