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During meiosis, the cell nucleus hosts a dynamic environment where some genes are transcriptionally activated, and some are inactivated at the same time. This becomes possible through subnuclear compartmentalization. The sex body, sequestering X and Y chromosomes during male meiosis and creating an environment for the meiotic sex chromosome inactivation (MSCI) is one of the best known and studied subnuclear compartments. Herein, we show that MRNIP forms droplet\u2010like accumulations that fuse together to create a distinct subnuclear compartment that partially overlaps with the sex body chromatin during diplotene. We demonstrate that\n                    <jats:italic>Mrnip<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    spermatocytes have impaired DNA double\u2010strand break (DSB) repair, they display reduced sex body formation and defective MSCI. We show that\n                    <jats:italic>Mrnip<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    undergoes critical meiocyte loss at the diplotene stage. Furthermore, we determine that DNA DSBs (induced by SPO11) and synapsis initiation (facilitated by SYCP1) precede\n                    <jats:italic>Mrnip<\/jats:italic>\n                    expression in testes. Altogether, our findings indicate that in addition to an emerging role in DNA DSB repair, MRNIP has an essential function in spermatogenesis during meiosis I by forming drop\u2010like accumulations interacting with the sex body.\n                  <\/jats:p>","DOI":"10.1096\/fj.202101168rr","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T05:25:20Z","timestamp":1659504320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>MRNIP<\/scp>\n                    interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice"],"prefix":"10.1096","volume":"36","author":[{"given":"Samina","family":"Kazi","sequence":"first","affiliation":[{"name":"Faculty of Biochemistry and Molecular Medicine University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio 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