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While extensive research has analyzed photoreceptors, less attention has been paid to these secondary defects. Here, we use different\n                    <jats:italic>Prph2<\/jats:italic>\n                    disease models to evaluate the damage of the RPE arising from photoreceptor defects. In\n                    <jats:italic>Prph2<\/jats:italic>\n                    disease models, the RPE exhibits structural abnormalities and cell loss. Furthermore, RPE functional defects are observed, including impaired clearance of phagocytosed outer segment material and increased microglia activation. The severity of RPE damage is different between models, suggesting that the different abnormal outer segment structures caused by\n                    <jats:italic>Prph2<\/jats:italic>\n                    disease mutations lead to varying degrees of RPE stress and thus influence the clinical phenotype observed in patients.\n                  <\/jats:p>","DOI":"10.1096\/fj.202101562rr","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T10:52:58Z","timestamp":1648464778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>Prph2<\/i>\n                    disease mutations lead to structural and functional defects in the RPE"],"prefix":"10.1096","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3081-6580","authenticated-orcid":false,"given":"Lars","family":"Tebbe","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Houston  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