{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:55:27Z","timestamp":1791190527847,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Spermatid production is a complex regulatory process in which coordination between hormonal control and apoptosis plays a pivotal role in maintaining a balanced number of sperm cells. Apoptosis in spermatogenesis is controlled by pro\u2010apoptotic and anti\u2010apoptotic molecules. Hormones involved in the apoptotic process during spermatogenesis include gonadotrophins, sex hormones, and glucocorticoid (GC). GC acts broadly as an apoptosis inducer by binding to its receptor (glucocorticoid receptor: GR) during organ development processes, such as spermatogenesis. However, the downstream pathway induced in GC\u2010GR signaling and the apoptotic process during spermatogenesis remains poorly understood. We reported previously that GC induces full\u2010length glucocorticoid\u2010induced transcript 1 (GLCCI1\u2010long), which functions as an anti\u2010apoptotic mediator in thymic T cell development. Here, we demonstrate that mature murine testis expresses a novel isoform of GLCCI1 protein (GLCCI1\u2010short) in addition to GLCCI1\u2010long. We demonstrate that GLCCI1\u2010long is expressed in spermatocytes along with GR. In contrast, GLCCI1\u2010short is primarily expressed in spermatids where GR is absent; instead, the estrogen receptor is expressed. GLCCI1\u2010short also binds to LC8, which is a known mediator of the anti\u2010apoptotic effect of GLCCI1\u2010long. A luciferase reporter assay revealed that \u03b2\u2010estradiol treatment synergistically increased\n                    <jats:italic>Glcci1<\/jats:italic>\n                    \u2010short promotor\u2010driven luciferase activity in Er\u03b1\u2010overexpressing cells. Together with the evidence that the conversion of testosterone to estrogen is preceded by aromatase expression in spermatids, we hypothesize that estrogen induces GLCCI1\u2010short, which, in turn, may function as a novel anti\u2010apoptotic mediator in mature murine testis.\n                  <\/jats:p>","DOI":"10.1096\/fj.202101667rr","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T07:52:35Z","timestamp":1670226755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Involvement of\n                    <scp>GLCCI1<\/scp>\n                    in mouse spermatogenesis"],"prefix":"10.1096","volume":"37","author":[{"given":"Masaru","family":"Takada","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kyorin University School of Medicine  Tokyo 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