{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:14:03Z","timestamp":1792174443777,"version":"4.4.0"},"reference-count":201,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aggregation of amyloidogenic proteins is a pathological hallmark of various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. In these diseases, oligomeric intermediates or toxic aggregates of amyloids cause neuronal damage and degeneration. Despite the substantial effort made over recent decades to implement therapeutic interventions, these neurodegenerative diseases are not yet understood at the molecular level. In many cases, multiple disease\u2010causing amyloids overlap in a sole pathological feature or a sole disease\u2010causing amyloid represents multiple pathological features. Various amyloid pathologies can coexist in the same brain with or without clinical presentation and may even occur in individuals without disease. From sparse data, speculation has arisen regarding the coaggregation of amyloids with disparate amyloid species and other biomolecules, which are the same characteristics that make diagnostics and drug development challenging. However, advances in research related to biomolecular condensates and structural analysis have been used to overcome some of these challenges. Considering the development of these resources and techniques, herein we review the cross\u2010seeding of amyloidosis, for example, involving the amyloids amyloid \u03b2, tau, \u03b1\u2010synuclein, and human islet amyloid polypeptide, and their cross\u2010inhibition by transthyretin and BRICHOS. The interplay of nucleic acid\u2010binding proteins, such as prions, TAR DNA\u2010binding protein 43, fused in sarcoma\/translated in liposarcoma, and fragile X mental retardation polyglycine, with nucleic acids in the pathology of neurodegeneration are also described, and we thereby highlight the potential clinical applications in central nervous system therapy.<\/jats:p>","DOI":"10.1096\/fj.202200235r","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T03:40:47Z","timestamp":1660621247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Interactions of amyloid coaggregates with biomolecules and its relevance to neurodegeneration"],"prefix":"10.1096","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3152-1784","authenticated-orcid":false,"given":"Kazuma","family":"Murakami","sequence":"first","affiliation":[{"name":"Division of Food Science and Biotechnology, Graduate School of Agriculture Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-6155","authenticated-orcid":false,"given":"Kenjiro","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medical Sciences Kanazawa University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0060-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-044518"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2017.08.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.189928"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033860"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3028"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506120500106958"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800036200"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101478"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90635-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi992933h"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50367.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3549"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-43"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1709-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R116.733428"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.304055.117"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.035"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806270105"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20814"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2991"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05129"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600749113"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12683-8"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.11.005"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905007106"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm7285"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23002"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04199-3"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1530287100"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-019-0248-4"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21912-y"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255555"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12481"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062097"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058189"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509386103"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211412398"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-006-9140-9"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003135"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07847.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.057"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.10.010"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.11.016"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66602-9"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1832-0"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77409-z"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4247"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2211-04.2004"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1919-07.2007"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.06.005"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b01475"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11030411"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13429"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-170051"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.014787"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66718-y"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2971"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02056-4"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160277"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715951115"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00269.x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000225908.90052.07"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-0983-7"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00343-1"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30291-5"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-017-2382-x"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2012.08.012"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27061776"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009106"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.1937"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00151a036"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12030446"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-2-180"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050923"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199902)45:2<174::AID-ANA7>3.0.CO;2-E"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.9.915"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2007.11.003"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.2741\/3611"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1204498109"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi030135s"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.11.006"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050702"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106707200"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi060532d"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks970"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2018.04.006"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.02.038"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt189"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2018.03.009"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67605"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04436-3"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008304200"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv679"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky391"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.11.012"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.00006"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101284"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd9440"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81163-0"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.519"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)01031-6"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa822"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.132"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0358-8"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63291-9"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00061.x"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC03053G"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050261"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050373"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi300440e"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200300589"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802102200"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01979"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/35081095"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku559"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030213"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2010.11.015"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01094"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000426"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.10.009"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.5.2106-2117.2006"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201308028"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00009.x"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02046.x"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-9260-1"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134108"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.093"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2012-0115"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-02042-8"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00025"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1088-7"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80272-X"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2698"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1407"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.015"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00335"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.11.018"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201504057"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1912055117"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013325"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.02.004"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c02424"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797452"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25767-0"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.07.071"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.038950"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800342200"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/363640a0"},{"key":"e_1_2_10_152_1","first-page":"724","article-title":"Identification of hnRNP P2 as TLS\/FUS using electrospray mass spectrometry","volume":"1","author":"Calvio C","year":"1995","journal-title":"RNA"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166066"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1165942"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091414544472"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.78"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000614"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.048"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103701"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-9-37"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201592559"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10465"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201302044"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593517"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq335"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.497974"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.110.15.1741"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408552200"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.049"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207247109"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10879"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90397-H"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.02.010"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02697-z"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.014"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2150"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.76"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00566-9"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.17.4803"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00568-2"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu586"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515737112"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050052"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi077"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404995101"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0018-6"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12365"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-021-02454-5"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108591"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46924"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9061301"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59364-x"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11084-009-9165-6"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-0878-9"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0630-0"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00235"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161017"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.50"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S289473"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03707.x"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00281"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.07.008"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202200235R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202200235R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202200235R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:16:01Z","timestamp":1761671761000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202200235R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":201,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1096\/fj.202200235R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202200235r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]},"assertion":[{"value":"2022-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22493"}}