{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:41:52Z","timestamp":1794004912601,"version":"4.8.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102016\u201005747"],"award-info":[{"award-number":["RGPIN\u20102016\u201005747"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cellular senescence is the irreversible arrest of normally dividing cells and is driven by the cell cycle inhibitors\n                    <jats:italic>Cdkn2a<\/jats:italic>\n                    ,\n                    <jats:italic>Cdkn1a<\/jats:italic>\n                    , and\n                    <jats:italic>Trp53<\/jats:italic>\n                    . Senescent cells are implicated in chronic diseases and tissue repair through their increased secretion of pro\u2010inflammatory factors known as the senescence\u2010associated secretory phenotype (SASP). Here, we use spatial transcriptomics and single\u2010cell RNA sequencing (scRNAseq) to demonstrate that cells displaying senescent characteristics are \u201ctransiently\u201d present within regenerating skeletal muscle and within the muscles of D2\u2010\n                    <jats:italic>mdx<\/jats:italic>\n                    mice, a model of Muscular Dystrophy. Following injury, multiple cell types including macrophages and fibrog\u2013adipogenic progenitors (FAPs) upregulate senescent features such as senescence pathway genes, SASP factors, and senescence\u2010associated beta\u2010gal (SA\u2010\u03b2\u2010gal) activity. Importantly, when these cells were removed with ABT\u2010263, a senolytic compound, satellite cells are reduced, and muscle fibers were impaired in growth and myonuclear accretion. These results highlight that an \u201cacute\u201d senescent phenotype facilitates regeneration similar to skin and neonatal myocardium.\n                  <\/jats:p>","DOI":"10.1096\/fj.202200289rr","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T09:55:15Z","timestamp":1664790915000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Muscle injury induces a transient senescence\u2010like state that is required for myofiber growth during muscle regeneration"],"prefix":"10.1096","volume":"36","author":[{"given":"Laura V.","family":"Young","sequence":"first","affiliation":[{"name":"Department of Applied Human Sciences University of Prince Edward Island  Charlottetown Prince Edward Island Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griffen","family":"Wakelin","sequence":"additional","affiliation":[{"name":"Department of Applied Human Sciences University of Prince Edward Island  Charlottetown Prince Edward Island Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alasdair W. 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Patrick","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Applied Human Sciences University of Prince Edward Island  Charlottetown Prince Edward Island Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel G.","family":"Arsenault","sequence":"additional","affiliation":[{"name":"Department of Applied Human Sciences University of Prince Edward Island  Charlottetown Prince Edward Island Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Kinesiology McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Collao","sequence":"additional","affiliation":[{"name":"School of Human Kinetics University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"De Lisio","sequence":"additional","affiliation":[{"name":"School of Human Kinetics University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Ljubicic","sequence":"additional","affiliation":[{"name":"Department of Kinesiology McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8875-6088","authenticated-orcid":false,"given":"Adam P. 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