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It has been reported that the inactivation of\n                    <jats:italic>Foxo1<\/jats:italic>\n                    in gonocytes during the embryonic stage causes the defects of spermatogenesis. In the present study, we found that the inactivation of\n                    <jats:italic>Foxo1<\/jats:italic>\n                    in spermatogonia after birth also caused germ cell loss and male infertility. We found that the initiation of meiosis was not affected; however, the germ cell development was arrested after meiosis and lack of mature spermatozoa in the cauda epididymis. We also found that the proliferation of\n                    <jats:italic>Foxo1\u2010<\/jats:italic>\n                    deficient spermatogonia stem cells was significantly reduced under in vitro conditions. Further study revealed that inactivation of\n                    <jats:italic>Pten<\/jats:italic>\n                    in postnatal spermatogonia using\n                    <jats:italic>Stra8\u2010Cre<\/jats:italic>\n                    did not affect germ cell development and the subcellular location of FOXO1 in\n                    <jats:italic>Pten\u2010<\/jats:italic>\n                    deficient spermatogonia. This study demonstrated that\n                    <jats:italic>Foxo1<\/jats:italic>\n                    was involved in the development of spermatogonia after birth and the function of\n                    <jats:italic>Foxo1<\/jats:italic>\n                    was probably not regulated by PI3K\/PTEN signaling.\n                  <\/jats:p>","DOI":"10.1096\/fj.202200640rr","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T05:14:48Z","timestamp":1662095688000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The function of\n                    <i>Foxo1<\/i>\n                    in spermatogonia development is independent of\n                    <scp>PI3K\/PTEN<\/scp>\n                    signaling"],"prefix":"10.1096","volume":"36","author":[{"given":"Zhiming","family":"Shen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology 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