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Analyze individual differences in radiation sensitivity using\n                    <jats:sup>60<\/jats:sup>\n                    Co radiation (0.27\u2009Gy\/min). Chromosomal aberrations with different irradiation dose rates were used to establish the biological dose curve and analyze the excess of the \u201cdicentric + ring\u201d caused by the dose rate at each dose point; DAPI\u2010images and Metafer 4 were used to capture metaphase images and make further analysis. The data were collected in 2020, Dicentric + ring\/100 Cells was 17.5\u201343.8, the average value was28.32\u2009\u00b1\u20096.98. The mean value of Dicentric + ring\/100 Cells was 31.37 in males while 25.27 in females, there are significant differences (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01). The irradiation dose is dominant, At each dose point, the value of\u201c(dicentric chromosome + centric rings)\/cell\u201d is proportional to \u201cdose rate\u201d, that is,\n                    <jats:italic>Y<\/jats:italic>\n                    \u00a0=\u00a0\n                    <jats:italic>kx<\/jats:italic>\n                    \u2009+\u2009\n                    <jats:italic>b<\/jats:italic>\n                    , within the dose range of 1\u20135\u2009Gy, \u201c(dicentric chromosome + centric rings)\/Cell\u201d holds a quadratic linear relationship with dose rate, that is,\n                    <jats:italic>y<\/jats:italic>\n                    \u00a0=\u00a0\n                    <jats:italic>ax<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009+\u2009\n                    <jats:italic>bx<\/jats:italic>\n                    \u2009+\u2009\n                    <jats:italic>c<\/jats:italic>\n                    ; The DAPI\u2010images might give you more hints than those of conventional Giemsa\u2010stain. The authors recommend that the IAEA Manual 2011 could be revised based on data of radio\u2010sensitivity and dose\u2010rate, which may contribute to the establishment of a unified dose\u2013response calibration curve and stimulation of potential for automation in cytogenetic biodosimetry. (1) Individual differences of radiosensitivity are very large. (2) At each dose point, \u201c(dicentric chromosome + centric rings)\/cell\u201d is proportional to \u201cdose rate\u201d, that is,\n                    <jats:italic>Y<\/jats:italic>\n                    \u00a0=\u00a0\n                    <jats:italic>kx<\/jats:italic>\n                    \u2009+\u2009\n                    <jats:italic>b<\/jats:italic>\n                    . (3) \u201c(dicentric chromosome + centric rings)\/Cell\u201d is a quadratic linear relationship with dose rate, that is,\n                    <jats:italic>y<\/jats:italic>\n                    \u00a0=\u00a0\n                    <jats:italic>ax<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009+\u2009\n                    <jats:italic>bx<\/jats:italic>\n                    \u2009+\u2009\n                    <jats:italic>c<\/jats:italic>\n                    . (4) We created a \u201cUnity Standard Curve of Biological Dose Estimation\u201d. Creating a Unity Standard Curve of Biological Dose, under these circumstances, we can form a joint and rapid response to a nuclear and radiological accident.\n                  <\/jats:p>","DOI":"10.1096\/fj.202200769rr","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T11:21:21Z","timestamp":1666178481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Revision of cytogenetic dosimetry in the\n                    <scp>IAEA<\/scp>\n                    manual 2011 based on data about radio\u2010sensitivity and dose\u2010rate findings contributing"],"prefix":"10.1096","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3153-7797","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"first","affiliation":[{"name":"Gansu Provincial Center for Disease Control and Prevention, Joint Laboratory of Institute of Radiology Chinese Academy of Medical Sciences  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