{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:36:39Z","timestamp":1782603399209,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072819"],"award-info":[{"award-number":["82072819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The incidence of androgen alopecia (AGA), also known as seborrheic alopecia, has surged in recent years, and onset is occurring at younger ages. Dermal papilla cells (DPCs) are key to maintaining hair cycling, and apoptosis\u2010driven processes in DPCs are closely related to hair follicle regeneration. Circular RNAs (circRNAs) are widely present in the human body and are closely related to the occurrence and development of many diseases. Currently, the biological functions of circRNAs in AGA are largely unknown. Whole\u2010transcriptome sequencing was used to screen differential circRNA expression profiles between AGA patients and non\u2010AGA patients. We found that hsa_circ_0002980 (circAGK) was significantly highly expressed in the AGA group. CircAGK promoted DPC apoptosis in the presence of high dihydrotestosterone (DHT) (15\u2009nmol\/L). By regulating the miR\u20103180\u20105p\/BAX axis, circAGK promotes DPC apoptosis in a high DHT environment in vitro and inhibits hair growth in AGA mice in vivo, indicating that circAGK is a potential target for the clinical treatment of AGA.<\/jats:p>","DOI":"10.1096\/fj.202200849r","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T10:07:51Z","timestamp":1672999671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>CircAGK<\/scp>\n                    regulates high dihydrotestosterone\u2010induced apoptosis in\n                    <scp>DPCs<\/scp>\n                    through the\n                    <scp>miR\u20103180\u20105p\/BAX<\/scp>\n                    axis"],"prefix":"10.1096","volume":"37","author":[{"given":"Hanxiao","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou 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